Paramagnetic Liposome Nanoparticles for Cellular and Tumour Imaging

被引：62

作者：

Kamaly, Nazila ^{[1
]}

Miller, Andrew D. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, Imperial Coll Genet Therapies Ctr, London SW7 2AZ, England

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2010年 / 11卷 / 04期

关键词：

cellular labeling; liposomes; Gadolinium; paramagnetic liposomes; bimodal liposomes; cellular imaging; tumour imaging; MRI; MRI contrast agents; nanoparticles; magnetic nanoparticles; MRI CONTRAST AGENTS; GADOLINIUM-LABELED LIPOSOMES; GD-DTPA; CATIONIC LIPIDS; CHELATING-AGENTS; GENE-TRANSFER; IN-VITRO; DELIVERY; ENHANCEMENT; LIPOPLEXES;

D O I：

10.3390/ijms11041759

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this review we discuss the development of paramagnetic liposomes incorporating MRI contrast agents and show how these are utilized in cellular imaging in vitro. Bi-functional, bi-modal imaging paramagnetic liposome systems are also described. Next we discuss the upgrading of paramagnetic liposomes into bi-modal imaging neutral nanoparticles for in vivo imaging applications. We discuss the development of such systems and show how paramagnetic liposomes and imaging nanoparticles could be developed as platforms for future multi-functional, multi-modal imaging theranostic nanodevices tailor-made for the combined imaging of early stage disease pathology and functional drug delivery.

引用

页码：1759 / 1776

页数：18

共 75 条

[1] Solvent 1H NMRD study of biotinylated paramagnetic liposomes containing Gd-bis-SDA-DTPA or Gd-DMPE-DTPA [J].