Role of Nasal Lavage Fluid Galactomannan Levels For Diagnosis of Invasive Aspergillosis in Patients with Leukemia

被引：2

作者：

Salehi, Mohammadreza ^{[1
]}

Hashemi, Seyed Jamal ^{[2
]}

Khodavaisy, Sadegh ^{[2
]}

Emami, Amir Hossein ^{[3
]}

SafaeeNodehi, Seyed Reza ^{[3
]}

Rasolinezhad, Mehrnaz ^{[1
]}

Ahmadikia, Kazem ^{[2
]}

DehghanManshadi, Seyed Ali ^{[1
]}

Abdollahi, Alireza ^{[4
]}

Amali, Amin ^{[5
]}

Mokhtarian, Maryam ^{[1
]}

机构：

[1] Univ Tehran Med Sci, Imam Khomeini Hosp Complex, Sch Med, Dept Infect Dis & Trop Med, Tehran, Iran

[2] Univ Tehran Med Sci, Sch Publ Hlth, Dept Med Parasitol & Mycol, Tehran, Iran

[3] Univ Tehran Med Sci, Dept Internal Med, Imam Khomeini Hosp Complex, Adult Hematol & Oncol Ward,Canc Inst, Tehran, Iran

[4] Univ Tehran Med Sci, Imam Khomeini Hosp Complex, Sch Med, Dept Pathol, Tehran, Iran

[5] Univ Tehran Med Sci, Otorhinolaryngol Res Ctr, Sch Med, Dept Otorhinolaryngol, Tehran, Iran

来源：

INTERNATIONAL JOURNAL OF CANCER MANAGEMENT | 2021年 / 14卷 / 04期

关键词：

Galactomannan; Nasal Lavage Fluid; Aspergillosis; Hematologic Neoplasms; Invasive Fungal Infections; PREEMPTIVE ANTIFUNGAL THERAPY; NEUTROPENIC PATIENTS; IMMUNOCOMPROMISED PATIENTS; CIRCULATING GALACTOMANNAN; FUNGAL-INFECTIONS; HIGH-RISK; FEBRILE; ANTIGEN; SERUM; ASSAY;

D O I：

10.5812/ijcm.103338

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Invasive aspergillosis (IA) is the most prevalent invasive infection with high mortality among patients with leukemia. Early diagnosis of IA has been a challenging topic in this group of patients. Objectives: In this study, we evaluated the galactomannan levels of nasal lavage fluid (NALF) as a possible auxiliary method for IA diagnosis in patients with leukemia. Methods: In a prospective study, 32 adult patients with leukemia who were taking induction and/or consolidation chemotherapy with fever and neutropenia were included. In all patients, galactomannan (GM) levels of serum and NALF, and mycological examinations were evaluated before the first dose of antifungal therapy. Results: Fourteen (43.7%) patients had NALF GM >= 0.5; however, in 16 (50%) patients the level of serum GM was >= 0.5. The elevated level of NALF GM had a significant association with the proven IA cases (P = 0.048). The GM level of NALF with a cut-off value of 0.45 (by receiver operating characteristic curve analysis) had 78% sensitivity and 64% specificity for the diagnosis of invasive aspergillosis (P = 0.033). Conclusions: Due to its non-invasive nature, GM level of NALF may be contributory to be used as part of the diagnostic work-up of IA particularly in leukemic patients with thrombocytopenia which prohibits acquiring bronchoalveolar lavage.

引用

页数：6

共 26 条

[1] Treatment with piperacillin-tazobactam and false-positive Aspergillus galactomannan antigen test results for patients with hematological malignancies [J].