Impaired adenosine-mediated angiogenesis in preeclampsia: potential implications for fetal programming

被引:33
作者
Escudero, Carlos [1 ]
Roberts, James M. [2 ,3 ]
Myatt, Leslie [4 ]
Feoktistov, Igor [5 ,6 ]
机构
[1] Univ Bio Bio, Vasc Physiol Lab, Grp Invest Tumor Angiogenesis, Grp Res & Innovat Vasc Hlth,Dept Basic Sci,Fac Sc, Chillan, Chile
[2] Univ Pittsburgh, Dept Epidemiol, Dept Obstet Gynecol & Reprod Sci, Magee Womens Res Inst, Pittsburgh, PA 15261 USA
[3] Univ Pittsburgh, Clin & Translat Sci Inst, Pittsburgh, PA USA
[4] Univ Texas Hlth Sci Ctr San Antonio, Ctr Pregnancy & Newborn Res, San Antonio, TX 78229 USA
[5] Vanderbilt Univ, Dept Med, Div Cardiovasc Med, Nashville, TN USA
[6] Vanderbilt Univ, Sch Med, Dept Pharmacol, Nashville, TN 37212 USA
来源
FRONTIERS IN PHARMACOLOGY | 2014年 / 5卷
关键词
adenosine receptors; angiogenesis; placenta; preeclampsia; programming; ENDOTHELIAL GROWTH-FACTOR; CARDIOVASCULAR RISK-FACTORS; HELSINKI BIRTH COHORT; NITRIC-OXIDE SYNTHASE; UMBILICAL-CORD BLOOD; RECEPTOR MESSENGER-RNA; MATERNAL PREECLAMPSIA; A(2A) RECEPTOR; DEAMINASE ACTIVITY; PROGENITOR CELLS;
D O I
10.3389/fphar.2014.00134
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Preeclampsia is a pregnancy-specific syndrome, defined by such clinical hallmarks as the onset of maternal hypertension and proteinuria after 20 weeks of gestation. The syndrome is also characterized by impaired blood flow through the utero-placental circulation and relative placental ischemia, which in turn, may generate feto-placental endothelial dysfunction. Endothelial dysfunction in offspring born from preeclamptic pregnancies has been associated with an increased risk of cardiovascular disease, including hypertension, later in life. Interestingly, diminished endothelial function, manifested by low angiogenic capacity, leads to hypertension in animal studies. Recently, we have shown that the adenosine receptor A2A/nitric oxide/vascular endothelial growth factor axis is reduced in human umbilical vein endothelial cells derived from preeclamptic pregnancies, an effect correlated with gestational age at onset of preeclampsia. We and others suggested that impaired vascular function might be associated with high cardiovascular risk in offspring exposed to pregnancy diseases. However, we are not aware of any studies that examine impaired adenosine-mediated angiogenesis as a possible link to hypertension in offspring born from preeclamptic pregnancies. In this review, we present evidence supporting the hypothesis that reduced adenosine-mediated angiogenesis during preeclamptic pregnancies might be associated with development of hypertension in the offspring.
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页数:13
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