ANGPTL8 in cardio-metabolic diseases

被引：6
作者：
Su, Xin [1 ]
Cheng, Ye [1 ]
Wang, Bin [1 ]
机构：
[1] Xiamen Univ, Xiamen Cardiovasc Hosp, Dept Cardiol, 2999 Jinshan Rd, Xiamen 361000, Fujian, Peoples R China
来源：
CLINICA CHIMICA ACTA | 2021年 / 519卷
关键词：
ANGPTL8; Dyslipidemia; Cardio-metabolic disorders; Glucose; Liver; Adipose tissue; ANGIOPOIETIN-LIKE PROTEINS; BETA-CELL PROLIFERATION; CIRCULATING BETATROPHIN LEVELS; GLUCOSE; LIPASIN; LEVEL; ANGPTL8/BETATROPHIN; ASSOCIATIONS; ADIPOCYTES; EXPRESSION;
D O I：
10.1016/j.cca.2021.05.017
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Dyslipidemia has been identified as an important factor in obesity, diabetes mellitus, and cardiovascular diseases (CVD), grouped as cardio-metabolic disorder diseases. Accordingly, dyslipidemia has become a major determinant in health worldwide. Both genome-wide association studies (GWAS) and research studies have focused on the elucidation of potential genetic mechanisms of dyslipidemia and the identification of new gene loci which contribute to the development of cardio-metabolic disorder diseases. Recent results indicate that both the ANGPTL8 gene and ANGPTL8 protein perform vital roles in modulating serum glucose and lipid metabolism. In this review, we examine the modulatory effects of ANGPTL8 and explore the potential mechanisms whereby ANGPTL8 affects serum glucose and lipid metabolism in cardio-metabolic disorder diseases.
引用
收藏
页码：260 / 266
页数：7
相关论文
共 83 条
[1]   The multi-faces of Angptl8 in health and disease: Novel functions beyond lipoprotein lipase modulation [J].
Abu-Farha, Mohamed ;
Ghosh, Anindya ;
Al-Khairi, Irina ;
Madiraju, S. R. Murthy ;
Abubaker, Jehad ;
Prentki, Marc .
PROGRESS IN LIPID RESEARCH, 2020, 80
[2]   The Rise and the Fall of Betatrophin/ANGPTL8 as an Inducer of β-Cell Proliferation [J].
Abu-Farha, Mohamed ;
Al Madhoun, Ashraf ;
Abubaker, Jehad .
JOURNAL OF DIABETES RESEARCH, 2016, 2016
[3]   ANGPTL8/Betatrophin R59W variant is associated with higher glucose level in non-diabetic Arabs living in Kuwaits [J].
Abu-Farha, Mohamed ;
Melhem, Motasem ;
Abubaker, Jehad ;
Behbehani, Kazem ;
Alsmadi, Osama ;
Elkum, Naser .
LIPIDS IN HEALTH AND DISEASE, 2016, 15
[4]   Circulating angiopoietin-like protein 8 (betatrophin) association with HsCRP and metabolic syndrome [J].
Abu-Farha, Mohamed ;
Abubaker, Jehad ;
Al-Khairi, Irina ;
Cherian, Preethi ;
Noronha, Fiona ;
Kavalakatt, Sina ;
Khadir, Abdelkrim ;
Behbehani, Kazem ;
Alarouj, Monira ;
Bennakhi, Abdullah ;
Elkum, Naser .
CARDIOVASCULAR DIABETOLOGY, 2016, 15
[5]   Lack of associations between betatrophin/ANGPTL8 level and C-peptide in type 2 diabetic subjects [J].
Abu-Farha, Mohamed ;
Abubaker, Jehad ;
Noronha, Fiona ;
Al-Khairi, Irina ;
Cherian, Preethi ;
Alarouj, Monira ;
Bennakhi, Abdullah ;
Elkum, Naser .
CARDIOVASCULAR DIABETOLOGY, 2015, 14
[6]   Higher plasma betatrophin/ANGPTL8 level in Type 2 Diabetes subjects does not correlate with blood glucose or insulin resistance [J].
Abu-Farha, Mohamed ;
Abubaker, Jehad ;
Al-Khairi, Irina ;
Cherian, Preethi ;
Noronha, Fiona ;
Hu, Frank B. ;
Behbehani, Kazem ;
Elkum, Naser .
SCIENTIFIC REPORTS, 2015, 5
[7]   Betatrophin The long awaited circulating factor from the liver promoting β-cell replication? [J].
Ahnfelt-Ronne, Jonas ;
Madsen, Ole D. .
ISLETS, 2014, 6 (02) :e28686-1
[8]  
Akinci B, 2000, Endotext
[9]   Angiopoietin-like proteins in multiple sclerosis [J].
Al-Temaimi, Rabeah ;
Cherian, Preethi ;
Abu-Farha, Mohamed ;
Alroughani, Raed .
JOURNAL OF NEUROIMMUNOLOGY, 2019, 330 :31-34
[10]   Human β-Cell Proliferation and Intracellular Signaling Part 2: Still Driving in the Dark Without a Road Map [J].
Bernal-Mizrachi, Ernesto ;
Kulkarni, Rohit N. ;
Scott, Donald K. ;
Mauvais-Jarvis, Franck ;
Stewart, Andrew F. ;
Garcia-Ocana, Adolfo .
DIABETES, 2014, 63 (03) :819-831
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