Expression of miR-128-3p, miR-193a-3p and miR-193a-5p in endometrial cancer tissues and their relationship with clinicopathological parameters

In order to explore the expression of microRNA-128-3p (miR-128-3p), microRNA-193a-3p (miR-193a-3p) and microRNA-193a-5p (miR-193a-5p) in the endometrial carcinoma and their relationship with clinicopathological parameters, the post-operative clinical samples of 61 endometrial cancer patients who underwent surgical resection in our hospital from February 2019 to February 2022 were collected as cancer tissues. The post-operative clinical samples of 61 normal endometrium patients who underwent surgical resection due to non-tumor diseases in our hospital were collected as para cancer tissues. miR-128-3p, miR-193a-3p and miR-193a-5p were measured by fluorescence quantitative polymerase, and the relationship between them and clinicopathological parameters and the correlation among them were analyzed. Results showed that miR-128-3p, miR-193a-3p and miR-193a-5p were lower in cancer tissues than in adjacent tissues (P<0.05). miR-128-3p, miR-193a-3p and miR-193a-5p were not related to the age and histopathological type of endometrial cancer patients (P>0.05). Still, they were related to FIGO stage, degree of differentiation, depth of myometrial invasion, lymph node metastasis and distant metastasis (P<0.05), and compared with FIGO stage I-II, medium and high differentiation, depth of myometrial invasion<1/2, no lymph node metastasis and no distant metastasis, FIGO stage III-IV, low differentiation miR-128-3p, miR-193a-3p and miR-193a-5p were lower in endometrial cancer patients with myometrial invasion depth >= 1/2, lymph node metastasis and distant metastasis (P<0.05). miR-128-3p, miR-193a-3p and miR-193a-5p were the risk factors of endometrial carcinoma (P<0.05). miR-128-3p and miR-193a-3p were positively correlated (r = 0.423, P = 0.001); miR-128-3p and miR-193a-5p were positively correlated (r = 0.342, P = 0.007); miR-193a-3p and miR-193a-5p were positively correlated (r = 0.555, P = 0.001). miR-128-3p, miR-193a-3p and miR-193a-5p are low expressed in the cancer tissues of endometrial cancer patients and are related to the adverse clinicopathological parameters of patients. They are expected to become potential prognostic markers and therapeutic targets of the disease.