Adenosine triphosphate/pH dual-responsive controlled drug release system with high cancer/normal cell selectivity and low side toxicity

被引：0
作者：
Fu, Bo [1 ]
Lin, Hui-Chao [2 ]
Chen, Nian [1 ]
Zhao, Ping [2 ]
机构：
[1] Zhongshan Torch Polytech, Coll Hlth Ind, Zhongshan, Guangdong, Peoples R China
[2] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Guangzhou 510006, Guangdong, Peoples R China
来源：
JOURNAL OF BIOMATERIALS APPLICATIONS | 2022年 / 37卷 / 02期
关键词：
drug-delivery systems; adenosine triphosphate; pH responsive; cancer; normal selectivity; biosafety; tumor suppression; MESOPOROUS SILICA; DELIVERY; NANOPARTICLES; ATP; DOXORUBICIN; STRATEGIES; ACID;
D O I：
10.1177/08853282221087412
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Most drug-delivery systems (DDS) suffer from poor selectivity to cancer/normal cells or the complicated synthetic process. Herein, we employed a novel facile method to develop an oligodeoxy nucleotides based DDS composed with adenosine-5(')- triphosphate (ATP) aptamer and a pH responsive cytosine (C) DNA fragment for specific daunomycine (DNM) delivery. The DDS has ATP/pH dual-responsive drug release, can selectively internalize into tumor cell lines and thus has ultrahigh cancer/normal cell selectivity over the individual drug. The non-chemical synthesis, controllable dual-responsive intracellular drug release, and high cancer/normal cell selectivity endowed the DDS high biocompatibility and significant tumor suppression.
引用
收藏
页码：324 / 332
页数：9
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