Ionic Liquids-Based Drug Delivery: a Perspective

被引：10
|
作者：
Lu, Yi [1 ,2 ,3 ]
Qi, Jianping [1 ,2 ]
Wu, Wei [1 ,2 ,3 ,4 ]
机构：
[1] Fudan Univ, Sch Pharm, Key Lab Smart Drug Delivery MOE, Shanghai 201203, Peoples R China
[2] Tongji Univ, Sch Med, Shanghai Skin Dis Hosp, Shanghai 200443, Peoples R China
[3] Fudan Zhangjiang Inst, Shanghai 201203, Peoples R China
[4] Fudan Univ, Pudong Med Ctr, Shanghai Pudong Hosp, Ctr Med Res & Innovat, Shanghai 201399, Peoples R China
来源：
PHARMACEUTICAL RESEARCH | 2022年 / 39卷 / 10期
关键词：
Ionic liquids; Drug delivery; Perspective;
D O I：
10.1007/s11095-022-03362-3
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A Abstract Ionic liquids (ILs) recently draw attention for addressing unmet needs in biomedicines. By converting solids into liquids, ILs are emerging as novel platforms to overcome some critical drawbacks associated with the application of solid or crystalline active pharmaceutical ingredients (APIs). ILs have shown promise in liquidizing or solubilizing APIs, or as green solvents, novel permeation enhancers or active ingredients, alone or synergistically with APIs. Meanwhile, challenges turn up in company with the deepening understanding of ILs as drug delivery carrier systems. This perspective aims to provide a sketchy overview on the status quo with specific attention paid to new problems arising from the utilization of ILs-based technologies in drug delivery.
引用
收藏
页码：2329 / 2334
页数：6
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