Tumor-necrosis factor is a master of T cell exhaustion

被引：12

作者：

Baxter, Amy E. ^{[1
,2
]}

Kaufmann, Daniel E. ^{[1
,2
]}

机构：

[1] Ctr Hosp Univ Montreal, Res Ctr, Montreal, PQ, Canada

[2] Univ Montreal, Montreal, PQ, Canada

来源：

NATURE IMMUNOLOGY | 2016年 / 17卷 / 05期

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; PERSISTENT LCMV INFECTION; FACTOR-ALPHA; ACTIVATION; EXPRESSION; BLOCKADE;

D O I：

10.1038/ni.3436

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chronic viral infections are characterized by ongoing inflammation and a dysfunctional T cell response, which results in a failure of the host to clear the pathogen. Now these two hallmarks of infection have been linked by the classic pro-inflammatory cytokine tumor-necrosis factor.

引用

页码：476 / 478

页数：4

共 11 条

[1] Tumor necrosis factor (TNF) system levels in human immunodeficiency virus-infected patients during highly active antiretroviral therapy:: Persistent TNF activation is associated with virologic and immunologic treatment failure [J].

Aukrust, P ;

Müller, F ;

Lien, E ;

Nordoy, I ;

Liabakk, NB ;

Kvale, D ;

Espevik, T ;

Froland, SS .

JOURNAL OF INFECTIOUS DISEASES, 1999, 179 (01) :74-82

[2] SERUM LEVELS OF TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) AND SOLUBLE TNF RECEPTORS IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION - CORRELATIONS TO CLINICAL, IMMUNOLOGICAL, AND VIROLOGICAL PARAMETERS [J].

AUKRUST, P ;

LIABAKK, NB ;

MULLER, F ;

LIEN, E ;

ESPEVIK, T ;

FROLAND, SS .

JOURNAL OF INFECTIOUS DISEASES, 1994, 169 (02) :420-424

[3] Tumor-necrosis factor impairs CD4+ T cell-mediated immunological control in chronic viral infection [J].

Beyer, Marc ;

Abdullah, Zeinab ;

Chemnitz, Jens M. ;

Maisel, Daniela ;

Sander, Jil ;

Lehmann, Clara ;

Thabet, Yasser ;

Shinde, Prashant V. ;

Schmidleithner, Lisa ;

Koehne, Maren ;

Trebicka, Jonel ;

Schierwagen, Robert ;

Hofmann, Andrea ;

Popov, Alexey ;

Lang, Karl S. ;

Oxenius, Annette ;

Buch, Thorsten ;

Kurts, Christian ;

Heikenwalder, Mathias ;

Faetkenheuer, Gerd ;

Lang, Philipp A. ;

Hartmann, Pia ;

Knolle, Percy A. ;

Schultze, Joachim L. .

NATURE IMMUNOLOGY, 2016, 17 (05) :593-+

[4] PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression [J].

Day, Cheryl L. ;

Kaufmann, Daniel E. ;

Kiepiela, Photini ;

Brown, Julia A. ;

Moodley, Eshia S. ;

Reddy, Sharon ;

Mackey, Elizabeth W. ;

Miller, Joseph D. ;

Leslie, Alasdair J. ;

DePierres, Chantal ;

Mncube, Zenele ;

Duraiswamy, Jaikumar ;

Zhu, Baogong ;

Eichbaum, Quentin ;

Altfeld, Marcus ;

Wherry, E. John ;

Coovadia, Hoosen M. ;

Goulder, Philip J. R. ;

Klenerman, Paul ;

Ahmed, Rafi ;

Freeman, Gordon J. ;

Walker, Bruce D. .

NATURE, 2006, 443 (7109) :350-354

[5] TUMOR NECROSIS FACTOR-ALPHA INDUCES EXPRESSION OF HUMAN IMMUNODEFICIENCY VIRUS IN A CHRONICALLY INFECTED T-CELL CLONE [J].

FOLKS, TM ;

CLOUSE, KA ;

JUSTEMENT, J ;

RABSON, A ;

DUH, E ;

KEHRL, JH ;

FAUCI, AS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (07) :2365-2368

[6] Use of tumor necrosis factor (TNF) inhibitors in patients with HIV/AIDS [J].

Gallitano, Stephanie M. ;

McDermott, Laura ;

Brar, Kanwaljit ;

Lowenstein, Eve .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2016, 74 (05) :974-980

[7] Nonpathogenic Simian Immunodeficiency Virus Infections [J].

Klatt, Nichole R. ;

Silvestri, Guido ;

Hirsch, Vanessa .

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2012, 2 (01)

[8] TUMOR NECROSIS FACTOR-ALPHA AND INTERLEUKIN-1 STIMULATE THE HUMAN IMMUNODEFICIENCY VIRUS ENHANCER BY ACTIVATION OF THE NUCLEAR FACTOR KAPPA-B [J].

OSBORN, L ;

KUNKEL, S ;

NABEL, GJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (07) :2336-2340

[9] Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling [J].

Teijaro, John R. ;

Cherie Ng ;

Lee, Andrew M. ;

Sullivan, Brian M. ;

Sheehan, Kathleen C. F. ;

Welch, Megan ;

Schreiber, Robert D. ;

de la Torre, Juan Carlos ;

Oldstone, Michael B. A. .

SCIENCE, 2013, 340 (6129) :207-211

[10] Molecular and cellular insights into T cell exhaustion [J].

Wherry, E. John ;

Kurachi, Makoto .

NATURE REVIEWS IMMUNOLOGY, 2015, 15 (08) :486-499

← 1 2 →