Synovium Derived Mesenchymal Stromal Cells (Sy-MSCs): A Promising Therapeutic Paradigm in the Management of Knee Osteoarthritis

被引：7

作者：

Jeyaraman, Madhan ^{[1
,2
,3
]}

Muthu, Sathish ^{[2
,3
,4
]}

Jeyaraman, Naveen ^{[3
,5
]}

Ranjan, Rajni ^{[1
]}

Jha, Saurabh Kumar ^{[2
,3
]}

Mishra, Prabhu ^{[3
]}

机构：

[1] Sharda Univ, Sch Med Sci & Res, Dept Orthopaed, Greater Noida, Uttar Pradesh, India

[2] Sharda Univ, Sch Engn & Technol, Dept Biotechnol, Greater Noida, Uttar Pradesh, India

[3] Int Assoc Stemcell & Regenerat Med IASRM, New Delhi, India

[4] Govt Med Coll Sr Hosp, Dept Orthopaed, Dindigul, Tamil Nadu, India

[5] MAHE Univ, Kasturba Med Coll, Dept Orthopaed, Manipal, Karnataka, India

来源：

INDIAN JOURNAL OF ORTHOPAEDICS | 2022年 / 56卷 / 01期

关键词：

Synovium; Mesenchymal stromal cell; Chondrogenicity; Osteoarthritis knee; INFRAPATELLAR FAT PAD; STEM-CELLS; ADIPOSE-TISSUE; BONE-MARROW; CHONDROGENIC DIFFERENTIATION; EXTRACELLULAR-MATRIX; CARTILAGE DEFECTS; PROGENITOR CELLS; REPAIR; MEMBRANE;

D O I：

10.1007/s43465-021-00439-w

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Synovium-derived mesenchymal stromal cell (Sy-MSC) is a newer member of the mesenchymal stromal cell families. The first successful demonstration of the mesenchymal stromal cell from the human synovial membrane was done in 2001 and since then its potential role for musculoskeletal regeneration has been keenly documented. The regenerative effects of Sy-MSCs are through paracrine signaling, direct cell-cell interactions, and extracellular vehicles. Sy-MSCs possess superior chondrogenicity than other sources of mesenchymal stromal cells. This article aims to outline the advancement of synovium-derived mesenchymal stromal cells along with a specific insight into the application for managing osteoarthritis knee.

引用

页码：1 / 15

页数：15

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