Effects of obesity on neuroinflammatory and neurochemical parameters in an animal model of reserpine-induced Parkinson's disease

被引：4

作者：

Cavalheiro, Eulla Keimili Fernandes Ferreira ^{[1
]}

da Silva, Larissa Espindola ^{[1
]}

Oliveira, Mariana Pacheco ^{[1
]}

Silva, Marina Goulart ^{[2
]}

Damiani, Adriani Paganini ^{[3
]}

Ribeiro, Catharina de Bem ^{[3
]}

Magenis, Marina Lummertz ^{[3
]}

Cucker, Luana ^{[4
]}

Michels, Monique ^{[4
]}

Joaquim, Larissa ^{[1
]}

Machado, Richard Simon ^{[1
]}

Vilela, Thais Cereser ^{[1
]}

Bitencourt, Rafael M. ^{[2
]}

Andrade, Vanessa M. ^{[3
]}

Dal-Pizzol, Felipe ^{[4
]}

Petronilho, Fabricia ^{[1
]}

Tuon, Talita ^{[1
]}

Rezin, Gislaine Tezza ^{[1
,5
]}

机构：

[1] Univ Southern Santa Catarina, Postgrad Program Hlth Sci, Lab Neurobiol Inflammatory & Metab Proc, Tubarao, SC, Brazil

[2] Univ Southern Santa Catarina, Postgrad Program Hlth Sci, Lab Behav Neurosci, Tubarao, SC, Brazil

[3] Univ Extremo Sul Catarinense, Univ Extremo Catarinense, Lab Biol Celular & Mol, Ave Univ 1105, Criciuma, SC, Brazil

[4] Univ Southern Santa Catarina, Grad Program Hlth Sci, Lab Expt Pathophysiol, Criciuma, SC, Brazil

[5] Universityof Southern Santa Catarina, Ave Jose Acacio Moreira 787, BR-88704900 Tubarao, SC, Brazil

来源：

BEHAVIOURAL BRAIN RESEARCH | 2022年 / 434卷

关键词：

Obesity; Parkinson's disease; Neuroinflammation; Oxidative stress; HIGH-FAT DIET; OXIDATIVE STRESS; ADIPOSE-TISSUE; INSULIN-RESISTANCE; MITOCHONDRIAL DYSFUNCTION; METABOLIC SYNDROME; SUBSTANTIA-NIGRA; INFLAMMATION; DOPAMINE; DAMAGE;

D O I：

10.1016/j.bbr.2022.114019

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Obesity is associated with low-grade chronic inflammation and oxidative stress, affecting the brain's reward system by decreasing dopaminergic neurotransmission. It is known that dopaminergic neurotransmission is also reduced in Parkinson's disease (PD), and high adiposity is considered a risk factor for the development of several neurodegenerative diseases, including PD. This study aimed to assess the effects of obesity on neuroinflammatory and neurochemical parameters in an animal model of reserpine-induced PD. The obese group showed increased inflammation and oxidative damage as well as inhibition of mitochondrial respiratory chain complexes I and II and DNA damage in the evaluated structures. The PD group did not show inflammation or mitochondrial dysfunction but exhibited oxidative damage in the hippocampus. The combination group (obesity + PD) showed reduced inflammation and oxidative stress and increased activity of complexes I and II of the mitochondrial respiratory chain in most of the analyzed structures. On the other hand, obesity + PD caused oxidative damage to proteins in the liver, prefrontal cortex, striatum, and cerebral cortex and oxidative stress in the hypothalamus, resulting in reduced catalase activity. Furthermore, the combination group showed DNA damage in blood, liver, and cerebral cortex. In conclusion, it was observed that the association of obesity and PD did not increase inflammation, oxidative stress, or mitochondrial dysfunction in most of the evaluated structures but increased oxidative damage and induced mechanisms that led to DNA damage in peripheral tissues and brain structures.

引用

页数：13

共 149 条

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