Antisense strategies for inhibition of tumor necrosis factor-alpha synthesis

被引：0

作者：

Hartmann, G ^{[1
]}

Krug, A ^{[1
]}

Bidlingmaier, M ^{[1
]}

Eigler, A ^{[1
]}

Endres, S ^{[1
]}

机构：

[1] UNIV MUNICH,KLINIKUM INNENSTADT,MED KLIN,D-8000 MUNICH,GERMANY

来源：

NUCLEOSIDES & NUCLEOTIDES | 1997年 / 16卷 / 5-6期

关键词：

D O I：

10.1080/07328319708002927

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The proinflammatory cytokine tumor necrosis factor-alpha (TNF) plays a key role in inflammatory disease. Antisense oligonucleotide-mediated inhibition of monocyte-derived TNF synthesis may provide a valuable tool for therapeutic intervention. We established a model allowing specific suppression of TNF synthesis by oligonucleotides.

引用

页码：629 / 634

页数：6

共 4 条

[1]

EIGLER A, 1997, IN PRESS IMMUNOL TOD

[2] Oligodeoxynucleotides enhance lipopolysaccharide-stimulated synthesis of tumor necrosis factor: Dependence on phosphorothioate modification and reversal by heparin [J].

Hartmann, G ;

Krug, A ;

WallerFontaine, K ;

Endres, S .

MOLECULAR MEDICINE, 1996, 2 (04) :429-438

[3]

HARTMANN G, 1996, IN PRESS ANTISENSE N

[4] CPG MOTIFS IN BACTERIAL-DNA TRIGGER DIRECT B-CELL ACTIVATION [J].

KRIEG, AM ;

YI, AK ;

MATSON, S ;

WALDSCHMIDT, TJ ;

BISHOP, GA ;

TEASDALE, R ;

KORETZKY, GA ;

KLINMAN, DM .

NATURE, 1995, 374 (6522) :546-549

← 1 →