Control of quorum sensing by a Burkholderia pseudomallei multidrug efflux pump

被引:57
作者
Chan, Ying Ying
Bian, Hao Sheng
Tan, Theresa May Chin
Mattmann, Margrith E.
Geske, Grant D.
Igarashi, Jun
Hatano, Tomomi
Suga, Hiroaki
Blackwell, Helen E.
Chua, Kim Lee
机构
[1] Natl Univ Singapore, Dept Biochem, Yong Loo Lin Sch Med, Singapore 117597, Singapore
[2] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA
[3] Univ Tokyo, Chem Biol & Biotechnol Lab, Ctr Adv Sci & Technol, RCAST,Meguro Ku, Tokyo 1538904, Japan
关键词
D O I
10.1128/JB.00003-07
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The Burkholderia pseudomallei KHW quorum-sensing systems produced N-octanoyl-homoserine lactone, N-decanoyl-homoserine lactone, N-(3-hydroxy)-octanoyl-homoserine lactone, N-(3-hydroxy)-decanoyl-homoserine lactone, N-(3-oxo)-decanoyl-homoserine lactone, and N-(3-oxo)-tetradecanoyl-homoserine lactone. The extracellular secretion of these acyl-homoserine lactones is dependent absolutely on the function of the R pseudomallei BpeAB-OprB efflux pump.
引用
收藏
页码:4320 / 4324
页数:5
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