Predicting functions from protein sequences - where are the bottlenecks?

被引：246
作者：
Bork, P
Koonin, EV
机构：
[1] European Mol Biol Lab, D-69012 Heidelberg, Germany
[2] Max Delbruck Ctr Mol Med, Berlin, Germany
[3] NCBI, NIH, Bethesda, MD USA
来源：
NATURE GENETICS | 1998年 / 18卷 / 04期
关键词：
D O I：
10.1038/ng0498-313
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The exponential growth of sequence data does not necessarily lead to an increase in knowledge about the functions of genes and their products. Prediction of function using comparative sequence analysis is extremely powerful but, if not performed appropriately, may also lead to the creation and propagation of assignment errors. While current homology detection methods can cope with the data flow, the identification, verification and annotation of functional features need to be drastically improved.
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收藏
页码：313 / 318
页数：6
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