Expectation violation and attention to pain jointly modulate neural gain in somatosensory cortex

被引:39
作者
Fardo, Francesca [1 ,2 ,3 ]
Auksztulewicz, Ryszard [4 ,5 ]
Allen, Micah [3 ,5 ]
Dietz, Martin J. [6 ]
Roepstorff, Andreas [2 ,6 ]
Friston, Karl J. [5 ]
机构
[1] Aarhus Univ, Dept Clin Med, Danish Pain Ctr, DK-8000 Aarhus, Denmark
[2] Aarhus Univ, Interacting Minds Ctr, DK-8000 Aarhus, Denmark
[3] UCL, Inst Cognit Neurosci, London WC1N 3AR, England
[4] Univ Oxford, Oxford Ctr Human Brain Act, Oxford OX3 7JX, England
[5] UCL, Wellcome Trust Ctr Neuroimaging, London WC1N 3BG, England
[6] Aarhus Univ, Ctr Functionally Integrat Neurosci, DK-8000 Aarhus, Denmark
基金
英国惠康基金;
关键词
RIGHT-HEMISPHERE DOMINANCE; FREE-ENERGY; MISMATCH NEGATIVITY; FUNCTIONAL-ANATOMY; EVOKED-POTENTIALS; SPATIAL ATTENTION; BRAIN; MECHANISMS; STIMULI; PERCEPTION;
D O I
10.1016/j.neuroimage.2017.03.041
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The neural processing and experience of pain are influenced by both expectations and attention. For example, the amplitude of event-related pain responses is enhanced by both novel and unexpected pain, and by moving the focus of attention towards a painful stimulus. Under predictive coding, this congruence can be explained by appeal to a precision-weighting mechanism, which mediates bottom-up and top-down attentional processes by modulating the influence of feedforward and feedback signals throughout the cortical hierarchy. The influence of expectation and attention on pain processing can be mapped onto changes in effective connectivity between or within specific neuronal populations, using a canonical microcircuit (CMC) model of hierarchical processing. We thus implemented a CMC within dynamic causal modelling for magnetoencephalography in human subjects, to investigate how expectation violation and attention to pain modulate intrinsic (within-source) and extrinsic (between-source) connectivity in the somatosensory hierarchy. This enabled us to establish whether both expectancy and attentional processes are mediated by a similar precision-encoding mechanism within a network of somatosensory, frontal and parietal sources. We found that both unexpected and attended pain modulated the gain of superficial pyramidal cells in primary and secondary somatosensory cortex. This modulation occurred in the context of increased lateralized recurrent connectivity between somatosensory and frontoparietal sources, driven by unexpected painful occurrences. Finally, the strength of effective connectivity parameters in Sl, S2 and IFG predicted individual differences in subjective pain modulation ratings. Our findings suggest that neuromodulatory gain control in the somatosensory hierarchy underlies the influence of both expectation violation and attention on cortical processing and pain perception.
引用
收藏
页码:109 / 121
页数:13
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