Spit for Science: launching a longitudinal study of genetic and environmental influences on substance use and emotional health at a large US university

被引：131

作者：

Dick, Danielle M. ^{[1
,2
,4
]}

Nasim, Aashir ^{[3
,5
]}

Edwards, Alexis C. ^{[1
,2
]}

Salvatore, Jessica E. ^{[1
,2
]}

Cho, Seung B. ^{[1
,2
]}

Adkins, Amy ^{[1
,2
,4
]}

Meyers, Jacquelyn ^{[1
,4
]}

Yan, Jia ^{[1
,4
]}

Cooke, Megan ^{[1
]}

Clifford, James ^{[1
]}

Goyal, Neeru ^{[1
]}

Halberstadt, Lisa ^{[1
]}

Ailstock, Kimberly ^{[1
]}

Neale, Zoe ^{[1
]}

Opalesky, Jill ^{[1
,2
]}

Hancock, Linda ^{[6
]}

Donovan, Kristen K. ^{[6
]}

Sun, Cuie ^{[1
]}

Riley, Brien ^{[1
,2
,4
]}

Kendler, Kenneth S. ^{[1
,2
]}

机构：

[1] Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Richmond, VA 23298 USA

[2] Virginia Commonwealth Univ, Dept Psychiat, Richmond, VA 23298 USA

[3] Virginia Commonwealth Univ, Dept Psychol, Richmond, VA 23298 USA

[4] Virginia Commonwealth Univ, Dept Human & Mol Genet, Richmond, VA 23298 USA

[5] Virginia Commonwealth Univ, Dept African Amer Studies, Richmond, VA 23298 USA

[6] Virginia Commonwealth Univ, Wellness Resource Ctr, Richmond, VA 23298 USA

来源：

FRONTIERS IN GENETICS | 2014年 / 5卷

关键词：

NATIONAL COMORBIDITY SURVEY; ALCOHOL-INDUCED BLACKOUTS; AGE-OF-ONSET; COLLEGE-STUDENTS; RESPONSE RATES; LIFE EVENTS; DISORDERS; DRINKING; ABUSE; PREVALENCE;

D O I：

10.3389/fgene.2014.00047

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Finding genes involved in complex behavioral outcomes, and understanding the pathways by which they confer risk, is a challenging task, necessitating large samples that are phenotypically well characterized across time. We describe an effort to create a university-wide research project aimed at understanding how genes and environments impact alcohol use and related substance use and mental health outcomes across time in college students. Nearly 70% of the incoming freshman class (N = 2715) completed on-line surveys, with 80% of the students from the fall completing spring follow-ups. 98% of eligible participants also gave DNA. The participants closely approximated the university population in terms of gender and racial/ethnic composition. Here we provide initial results on alcohol use outcomes from the first wave of the sample, as well as associated predictor variables. We discuss the potential for this kind of research to advance our understanding of genetic and environment influences on substance use and mental health outcomes.

引用

页数：12

共 48 条

[1]

[Anonymous], 1993, Psychological Assessment, DOI [10.1037/1040-3590.5.1.19, DOI 10.1037/1040-3590.5.1.19]

[2] Community studies on adolescent substance use, abuse, or dependence and psychiatric comorbidity [J].