Synthesis of novel β-lactam fused spiroisoxazolidine chromanones and tetralones as potent antimicrobial agent for human and plant pathogens

被引：41

作者：

Arumugam, Natarajan ^{[1
]}

Raghunathan, Raghavachary ^{[1
]}

Shanmugaiah, Vellaisamy ^{[2
]}

Mathivanan, Narayanasamy ^{[2
]}

机构：

[1] Univ Madras, Dept Organ Chem, Madras 600025, Tamil Nadu, India

[2] Univ Madras, Ctr Adv Studies Bot, Madras 600025, Tamil Nadu, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 12期

关键词：

1,3-Dipolar cycloaddition; beta-Lactam; Spiroisoxazolidine; Microwave; 1,3-DIPOLAR CYCLOADDITION REACTION; STEREOSELECTIVE-SYNTHESIS; INHIBITORY CONCENTRATION; NUCLEOSIDES; DERIVATIVES; DESIGN;

D O I：

10.1016/j.bmcl.2010.04.084

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis of novel beta-lactam fused spiroisoxazolidine chromanones and tetralones ring systems has been achieved by intermolecular 1,3-dipolar cycloaddition reaction of bicyclic nitrone with unusual dipolarophiles, arylidene chromanones/tetralones under different reaction conditions. The synthesized compounds were evaluated for antimicrobial activities. It was observed that two of the synthesized compounds exhibited relatively good antibacterial and antifungal activities. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：3698 / 3702

页数：5

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