Synthesis and biological evaluation of dialkylsubstituted maleic anhydrides as novel inhibitors of Cdc25 dual specificity phosphatases

被引：34

作者：

Brault, Laurent ^{[1
]}

Denance, Mickael ^{[1
]}

Banaszak, Estelle ^{[1
]}

El Maadidi, Souhayla ^{[1
]}

Battaglia, Eric ^{[1
]}

Bagrel, Denyse ^{[1
]}

Samadi, Mohammad ^{[1
]}

机构：

[1] Univ Paul Verlaine, LIMBP, F-57078 Metz, France

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2007年 / 42卷 / 02期

关键词：

Barton decarboxylation; maleic anhydride; Cdc25; inhibition;

D O I：

10.1016/j.ejmech.2006.09.014

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An efficient synthesis of dialkyl substituted maleic anhydrides 1a-j is described. The inhibitory potential of these original anhydride derivatives was tested toward the three human isoforms A, B and C of dual specific phosphatases Cdc25. A micromolar range inhibition of Cdc25s was observed with the maleic anhydrides bearing simple alkyl side chains longer than C-9, to reach the optimal activity with a C-17 chain length. (c) 2006 Elsevier Masson SAS. All rights reserved.

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收藏

页码：243 / 247

页数：5

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