Pleiotropic function of Toll-like receptors

被引:106
作者
Kaisho, T
Akira, S
机构
[1] Osaka Univ, Dept Host Defense, Microbial Dis Res Inst, Suita, Osaka 5650871, Japan
[2] RIKEN, Res Ctr Allergy & Immunol, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan
[3] Japan Sci & Technol Corp, Akira Innate Immun Project, ERATO, Suita, Osaka 5650871, Japan
关键词
Toll-like receptor; innate immunity; adaptive immunity; dendritic cells;
D O I
10.1016/j.micinf.2004.08.019
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A group of type I transmembrane proteins, Toll-like receptors (TLRs) discriminate various microorganism-associated molecular structures that can function as immune adjuvants. Each TLR signaling has an overlapping but distinct function, which largely depends on intracellular adaptor molecules. Clarifying the functions and signaling of TLRs should provide us with critical information for manipulating the host defense mechanism. (C) 2004 Elsevier SAS. All rights reserved.
引用
收藏
页码:1388 / 1394
页数:7
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