共 34 条
Pleiotropic function of Toll-like receptors
被引:106
作者:

Kaisho, T
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Dept Host Defense, Microbial Dis Res Inst, Suita, Osaka 5650871, Japan

Akira, S
论文数: 0 引用数: 0
h-index: 0
机构: Osaka Univ, Dept Host Defense, Microbial Dis Res Inst, Suita, Osaka 5650871, Japan
机构:
[1] Osaka Univ, Dept Host Defense, Microbial Dis Res Inst, Suita, Osaka 5650871, Japan
[2] RIKEN, Res Ctr Allergy & Immunol, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan
[3] Japan Sci & Technol Corp, Akira Innate Immun Project, ERATO, Suita, Osaka 5650871, Japan
关键词:
Toll-like receptor;
innate immunity;
adaptive immunity;
dendritic cells;
D O I:
10.1016/j.micinf.2004.08.019
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
A group of type I transmembrane proteins, Toll-like receptors (TLRs) discriminate various microorganism-associated molecular structures that can function as immune adjuvants. Each TLR signaling has an overlapping but distinct function, which largely depends on intracellular adaptor molecules. Clarifying the functions and signaling of TLRs should provide us with critical information for manipulating the host defense mechanism. (C) 2004 Elsevier SAS. All rights reserved.
引用
收藏
页码:1388 / 1394
页数:7
相关论文
共 34 条
- [1] Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3[J]. NATURE, 2001, 413 (6857) : 732 - 738Alexopoulou, L论文数: 0 引用数: 0 h-index: 0机构: Immunobiol Sect, New Haven, CT 06520 USAHolt, AC论文数: 0 引用数: 0 h-index: 0机构: Immunobiol Sect, New Haven, CT 06520 USAMedzhitov, R论文数: 0 引用数: 0 h-index: 0机构: Immunobiol Sect, New Haven, CT 06520 USAFlavell, RA论文数: 0 引用数: 0 h-index: 0机构: Immunobiol Sect, New Haven, CT 06520 USA Immunobiol Sect, New Haven, CT 06520 USA
- [2] Tlr4: central component of the sole mammalian LPS sensor[J]. CURRENT OPINION IN IMMUNOLOGY, 2000, 12 (01) : 20 - 26Beutler, B论文数: 0 引用数: 0 h-index: 0机构: Univ Texas, SW Med Ctr, Dept Internal Med, Howard Hughes Med Inst, Dallas, TX 75235 USA Univ Texas, SW Med Ctr, Dept Internal Med, Howard Hughes Med Inst, Dallas, TX 75235 USA
- [3] Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA[J]. SCIENCE, 2004, 303 (5663) : 1529 - 1531Diebold, SS论文数: 0 引用数: 0 h-index: 0机构: London Res Inst, Canc Res UK, Immunobiol Lab, London WC2A 3PX, EnglandKaisho, T论文数: 0 引用数: 0 h-index: 0机构: London Res Inst, Canc Res UK, Immunobiol Lab, London WC2A 3PX, EnglandHemmi, H论文数: 0 引用数: 0 h-index: 0机构: London Res Inst, Canc Res UK, Immunobiol Lab, London WC2A 3PX, EnglandAkira, S论文数: 0 引用数: 0 h-index: 0机构: London Res Inst, Canc Res UK, Immunobiol Lab, London WC2A 3PX, EnglandSousa, CRE论文数: 0 引用数: 0 h-index: 0机构: London Res Inst, Canc Res UK, Immunobiol Lab, London WC2A 3PX, England London Res Inst, Canc Res UK, Immunobiol Lab, London WC2A 3PX, England
- [4] Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (12) : 1645 - 1651Eisenbarth, SC论文数: 0 引用数: 0 h-index: 0机构: Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USAPiggott, DA论文数: 0 引用数: 0 h-index: 0机构: Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USAHuleatt, JW论文数: 0 引用数: 0 h-index: 0机构: Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USAVisintin, I论文数: 0 引用数: 0 h-index: 0机构: Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USAHerrick, CA论文数: 0 引用数: 0 h-index: 0机构: Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USABottomly, K论文数: 0 引用数: 0 h-index: 0机构: Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA
- [5] IKKε and TBK1 are essential components of the IRF3 signaling pathway[J]. NATURE IMMUNOLOGY, 2003, 4 (05) : 491 - 496Fitzgerald, KA论文数: 0 引用数: 0 h-index: 0机构: Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USAMcWhirter, SM论文数: 0 引用数: 0 h-index: 0机构: Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USAFaia, KL论文数: 0 引用数: 0 h-index: 0机构: Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USARowe, DC论文数: 0 引用数: 0 h-index: 0机构: Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USALatz, E论文数: 0 引用数: 0 h-index: 0机构: Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USAGolenbock, DT论文数: 0 引用数: 0 h-index: 0机构: Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USACoyle, AJ论文数: 0 引用数: 0 h-index: 0机构: Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USALiao, SM论文数: 0 引用数: 0 h-index: 0机构: Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USAManiatis, T论文数: 0 引用数: 0 h-index: 0机构: Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA
- [6] The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5[J]. NATURE, 2001, 410 (6832) : 1099 - 1103Hayashi, F论文数: 0 引用数: 0 h-index: 0机构: Inst Syst Biol, Seattle, WA 98195 USASmith, KD论文数: 0 引用数: 0 h-index: 0机构: Inst Syst Biol, Seattle, WA 98195 USAOzinsky, A论文数: 0 引用数: 0 h-index: 0机构: Inst Syst Biol, Seattle, WA 98195 USAHawn, TR论文数: 0 引用数: 0 h-index: 0机构: Inst Syst Biol, Seattle, WA 98195 USAYi, EC论文数: 0 引用数: 0 h-index: 0机构: Inst Syst Biol, Seattle, WA 98195 USAGoodlett, DR论文数: 0 引用数: 0 h-index: 0机构: Inst Syst Biol, Seattle, WA 98195 USAEng, JK论文数: 0 引用数: 0 h-index: 0机构: Inst Syst Biol, Seattle, WA 98195 USAAkira, S论文数: 0 引用数: 0 h-index: 0机构: Inst Syst Biol, Seattle, WA 98195 USAUnderhill, DM论文数: 0 引用数: 0 h-index: 0机构: Inst Syst Biol, Seattle, WA 98195 USAAderem, A论文数: 0 引用数: 0 h-index: 0机构: Inst Syst Biol, Seattle, WA 98195 USA
- [7] Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8[J]. SCIENCE, 2004, 303 (5663) : 1526 - 1529Heil, F论文数: 0 引用数: 0 h-index: 0机构: Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-81675 Munich, GermanyHemmi, H论文数: 0 引用数: 0 h-index: 0机构: Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-81675 Munich, GermanyHochrein, H论文数: 0 引用数: 0 h-index: 0机构: Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-81675 Munich, GermanyAmpenberger, F论文数: 0 引用数: 0 h-index: 0机构: Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-81675 Munich, GermanyKirschning, C论文数: 0 引用数: 0 h-index: 0机构: Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-81675 Munich, GermanyAkira, S论文数: 0 引用数: 0 h-index: 0机构: Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-81675 Munich, GermanyLipford, G论文数: 0 引用数: 0 h-index: 0机构: Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-81675 Munich, GermanyWagner, H论文数: 0 引用数: 0 h-index: 0机构: Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-81675 Munich, GermanyBauer, S论文数: 0 引用数: 0 h-index: 0机构: Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-81675 Munich, Germany
- [8] Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway[J]. NATURE IMMUNOLOGY, 2002, 3 (02) : 196 - 200Hemmi, H论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Suita, Osaka 5650871, JapanKaisho, T论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Suita, Osaka 5650871, JapanTakeuchi, O论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Suita, Osaka 5650871, JapanSato, S论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Suita, Osaka 5650871, JapanSanjo, H论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Suita, Osaka 5650871, JapanHoshino, K论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Suita, Osaka 5650871, JapanHoriuchi, T论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Suita, Osaka 5650871, JapanTomizawa, H论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Suita, Osaka 5650871, JapanTakeda, K论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Suita, Osaka 5650871, JapanAkira, S论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Suita, Osaka 5650871, Japan
- [9] The roles of toll-like receptor 9, MyD88, and DNA-depondent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets[J]. JOURNAL OF IMMUNOLOGY, 2003, 170 (06) : 3059 - 3064Hemmi, H论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Dept Host Def, Microbial Dis Res Inst, Suita, Osaka 5650871, JapanKaisho, T论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Dept Host Def, Microbial Dis Res Inst, Suita, Osaka 5650871, JapanTakeda, K论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Dept Host Def, Microbial Dis Res Inst, Suita, Osaka 5650871, JapanAkira, S论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Dept Host Def, Microbial Dis Res Inst, Suita, Osaka 5650871, Japan
- [10] A Toll-like receptor recognizes bacterial DNA[J]. NATURE, 2000, 408 (6813) : 740 - 745Hemmi, H论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Osaka 5650871, JapanTakeuchi, O论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Osaka 5650871, JapanKawai, T论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Osaka 5650871, JapanKaisho, T论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Osaka 5650871, JapanSato, S论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Osaka 5650871, JapanSanjo, H论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Osaka 5650871, JapanMatsumoto, M论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Osaka 5650871, JapanHoshino, K论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Osaka 5650871, JapanWagner, H论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Osaka 5650871, JapanTakeda, K论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Osaka 5650871, JapanAkira, S论文数: 0 引用数: 0 h-index: 0机构: Osaka Univ, Microbial Dis Res Inst, Dept Host Def, Osaka 5650871, Japan