The influence of gender on 'tissue at risk' in acute stroke: A diffusion-weighted magnetic resonance imaging study in a rat model of focal cerebral ischaemia

被引：10
作者：
Baskerville, Tracey A. [1 ]
Macrae, I. Mhairi [1 ]
Holmes, William M. [1 ]
McCabe, Christopher [1 ]
机构：
[1] Univ Glasgow, Inst Neurosci & Psychol, Coll Med Vet & Life Sci MVLS, Glasgow Expt MRI Ctr GEMRIC, Glasgow G61 1QH, Lanark, Scotland
来源：
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2016年 / 36卷 / 02期
关键词：
Acute stroke; diffusion-weighted MRI; gender; MCAO; ARTERY OCCLUSION; PENUMBRA; MRI; ESTROGEN; MISMATCH; THERAPY;
D O I：
10.1177/0271678X15606137
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This is the first study to assess the influence of sex on the evolution of ischaemic injury and penumbra. Permanent middle cerebral artery occlusion was induced in male (n = 9) and female (n = 10) Sprague-Dawley rats. Diffusion-weighted imaging was acquired over 4 h and infarct determined from T-2 images at 24 h post-permanent middle cerebral artery occlusion. Penumbra was determined retrospectively from serial apparent diffusion coefficient lesions and T-2-defined infarct. Apparent diffusion coefficient lesion volume was significantly smaller in females from 0.5 to 4 h post permanent middle cerebral artery occlusion as was infarct volume. Penumbral volume, and its loss over time, was not significantly different despite the sex difference in acute and final lesion volumes.
引用
收藏
页码：381 / 386
页数：6
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