Pharmacologic treatment of atrophic age-related macular degeneration

被引：18
作者：
Mata, Nathan L. [1 ]
Vogel, Roger [1 ]
机构：
[1] Sirion Therapeut Inc, Tampa, FL 33619 USA
来源：
CURRENT OPINION IN OPHTHALMOLOGY | 2010年 / 21卷 / 03期
关键词：
age-related macular degeneration; drusen; dry AMD; geographic atrophy; lipofuscin; retina; retinal pigment epithelium; RPE; CILIARY NEUROTROPHIC FACTOR; COMPLEMENT FACTOR-H; CHOROIDAL BLOOD-FLOW; GEOGRAPHIC ATROPHY; FUNDUS AUTOFLUORESCENCE; OXIDATIVE STRESS; PHOTORECEPTOR DEGENERATION; DISEASE PROGRESSION; RETINAL STRUCTURE; FACTOR-RECEPTOR;
D O I：
10.1097/ICU.0b013e32833866c8
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Purpose of review To review and compare the various therapeutic platforms, investigational drugs, and clinical trials targeting geographic atrophy in age-related macular degeneration. Recent findings Investigational agents based on hypothesized causes are being developed to treat geographic atrophy. These platforms are designed to attack the disease on several different fronts. Summary As knowledge of geographic atrophy pathophysiology advances, targeted pharmacotherapies may well be able to mitigate the retinal damage and vision loss associated with geographic atrophy.
引用
收藏
页码：190 / 196
页数：7
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