A new pair of cytotoxic enantiomeric isoprenylated chromone derivatives from Pestalotiopsis sp.

被引：2

作者：

Yang, Bei-Ye ^{[1
]}

Sun, Wei-Guang ^{[1
]}

Liu, Jun-Jun ^{[1
]}

Wang, Jian-Ping ^{[1
]}

Hu, Zheng-Xi ^{[1
]}

Zhang, Yong-Hui ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430074, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2022年 / 24卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Fungus; Pestalotiopsis sp; enantiomers; ECD calculation; cytotoxicity;

D O I：

10.1080/10286020.2021.1946042

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new pair of enantiomeric isoprenylated chromone derivatives, (+/-)-pestaloficiol X [(+/-)-1], along with a known compound pestaloficiol J (2), were isolated from the plant endophytic fungus Pestalotiopsis sp. The racemic mixture 1 was separated through chiral HPLC. The structures of new compounds (+/-)-1 were elucidated on the basis of extensive spectroscopic data and their absolute configurations were further configured through computational analysis of their electronic circular dichroism (ECD) spectra. Compound (+)-1 showed significant inhibitory potency against HL-60 and HEP-3B cell lines, with IC50 values of 1.35 +/- 0.15 and 3.70 +/- 0.33 mu M, respectively, while compound (-)-1 showed significant inhibitory potency against HL-60 and HEP-3B cell lines, with IC50 values of 2.39 +/- 0.26 and 2.99 +/- 0.35 mu M, respectively.

引用

页码：528 / 534

页数：7

共 16 条

[11] Endophytes: a rich source of functional metabolites [J].

Tan, RX ;

Zou, WX .

NATURAL PRODUCT REPORTS, 2001, 18 (04) :448-459

[12] Generating conformer ensembles using a multiobjective genetic algorithm [J].

Vainio, Mikko J. ;

Johnson, Mark S. .

JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2007, 47 (06) :2462-2474

[13] Cytotoxic butenolides and diphenyl ethers from the endophytic fungus Pestalotiopsis sp. [J].

Yang, Beiye ;

Tong, Qingyi ;

Lin, Shuang ;

Guo, Jieru ;

Zhang, Jinwen ;

Liu, Junjun ;

Wang, Jianping ;

Zhu, Hucheng ;

Hu, Zhengxi ;

Zhang, Yonghui .

PHYTOCHEMISTRY LETTERS, 2019, 29 :186-189

[14] A New Breviane Spiroditerpenoid from the Marine-Derived Fungus Penicillium sp TJ403-1 [J].

Yang, Beiye ;

Sun, Weiguang ;

Wang, Jianping ;

Lin, Shuang ;

Li, Xiao-Nian ;

Zhu, Hucheng ;

Luo, Zengwei ;

Xue, Yongbo ;

Hu, Zhengxi ;

Zhang, Yonghui .

MARINE DRUGS, 2018, 16 (04)

[15] Biology and chemistry of endophytes [J].

Zhang, Hua Wei ;

Song, Yong Chun ;

Tan, Ren Xiang .

NATURAL PRODUCT REPORTS, 2006, 23 (05) :753-771

[16] Genetic Manipulation of the COP9 Signalosome Subunit PfCsnE Leads to the Discovery of Pestaloficins in Pestalotiopsis fici [J].

Zheng, Yanjing ;

Ma, Ke ;

Lyu, Haining ;

Huang, Ying ;

Liu, Hongwei ;

Liu, Ling ;

Che, Yongsheng ;

Liu, Xingzhong ;

Zou, Huixi ;

Yin, Wen-Bing .

ORGANIC LETTERS, 2017, 19 (17) :4700-4703

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