A new pair of cytotoxic enantiomeric isoprenylated chromone derivatives from Pestalotiopsis sp.

被引：2
作者：
Yang, Bei-Ye [1 ]
Sun, Wei-Guang [1 ]
Liu, Jun-Jun [1 ]
Wang, Jian-Ping [1 ]
Hu, Zheng-Xi [1 ]
Zhang, Yong-Hui [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430074, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2022年 / 24卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Fungus; Pestalotiopsis sp; enantiomers; ECD calculation; cytotoxicity;
D O I：
10.1080/10286020.2021.1946042
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new pair of enantiomeric isoprenylated chromone derivatives, (+/-)-pestaloficiol X [(+/-)-1], along with a known compound pestaloficiol J (2), were isolated from the plant endophytic fungus Pestalotiopsis sp. The racemic mixture 1 was separated through chiral HPLC. The structures of new compounds (+/-)-1 were elucidated on the basis of extensive spectroscopic data and their absolute configurations were further configured through computational analysis of their electronic circular dichroism (ECD) spectra. Compound (+)-1 showed significant inhibitory potency against HL-60 and HEP-3B cell lines, with IC50 values of 1.35 +/- 0.15 and 3.70 +/- 0.33 mu M, respectively, while compound (-)-1 showed significant inhibitory potency against HL-60 and HEP-3B cell lines, with IC50 values of 2.39 +/- 0.26 and 2.99 +/- 0.35 mu M, respectively.
引用
收藏
页码：528 / 534
页数：7
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