Absorption, distribution, metabolism and excretion of hyaluronic acid during pregnancy: a matter of molecular weight

被引:10
作者
Unfer, Vittorio [1 ]
Tilotta, Marco [2 ]
Kaya, Cihan [3 ]
Noventa, Marco [4 ]
Torok, Peter [5 ]
Alkatout, Ibrahim [6 ]
Gitas, Georgios [7 ]
Bilotta, Gabriele [8 ]
Lagana, Antonio Simone [9 ]
机构
[1] Syst Biol Grp Lab, Rome, Italy
[2] Lo Li Pharma Srl, B&R Dept, Rome, Italy
[3] Univ Hlth Sci, Dept Obstet & Gynaecol, Bakirkoy Dr Sadi Konuk Training & Res Hosp, Istanbul, Turkey
[4] Univ Padua, Clin Gynecol & Obstet, Dept Women & Childrens Hlth, Padua, Italy
[5] Univ Debrecen, Inst Obstet & Gynecol, Fac Med, Debrecen, Hungary
[6] Univ Hosp Schleswig Holstein, Dept Obstet & Gynecol, Kiel, Germany
[7] Univ Hosp Schleswig Holstein, Dept Obstet & Gynecol, Lubeck, Germany
[8] Univ Insubria, Alma Res Fertil Ctr, Rome, Italy
[9] Univ Insubria, Filippo Del Ponte Hosp, Dept Obstet & Gynecol, Piazza Biroldi 1, I-21100 Varese, Italy
关键词
Hyaluronic acid; high-molecular-weight hyaluronic acid; absorption; pregnancy; recurrent miscarriage; preeclampsia; pre-term birth; DECIDUAL STROMAL CELLS; PRETERM PREMATURE RUPTURE; ACTIVATED PROTEIN-KINASE; IN-VITRO FERTILIZATION; MURAL GRANULOSA-CELLS; HUMAN FETAL MEMBRANES; PROGESTERONE-RECEPTOR; OOCYTE MATURATION; CUMULUS CELLS; TROPHOBLAST INVASION;
D O I
10.1080/17425255.2021.1931682
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Introduction For many years hyaluronic acid (HA) was mainly used for its hydrating properties. However, new applications have recently arisen, considering the biological properties of HA and its molecular weight. Clinical application of low molecular weight HA (LMW-HA) initially was supported by specific absorption data. The identification of high molecular weight HA (HMW-HA) absorption pathways and the knowledge of its physiological role allowed to evaluate its clinical application. Based on the immunomodulatory properties of HMW-HA and its physiological involvement as signaling molecule, pregnancy represents an interesting context of application. Area covered This expert opinion includes in-vitro, in-vivo, ex-vivo and clinical studies on gestational models. It provides an overview of the physiological and the therapeutic role of HMW-HA in pregnancy starting from its metabolism. Indeed, HMW-HA is widely involved in several physiological processes as implantation, immune response, uterine quiescence and cervical remodeling, and therefore is an essential molecule for a successful pregnancy. Expert opinion Available evidence suggests that HMW-HA administration can support physiological pregnancy, favoring blastocyst adhesion and development, preventing miscarriage and pre-term birth. For this reason, supplementation in pregnancy should be evaluated.
引用
收藏
页码:823 / 840
页数:18
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