Lanthanide(III) triflate-catalyzed thermal- and microwave-assisted synthesis of benzyl ethers from benzyl alcohols

被引：10

作者：

Handlon, AL ^{[1
]}

Guo, Y ^{[1
]}

机构：

[1] GlaxoSmithKline, Dept Med Chem, Res Triangle Pk, NC 27709 USA

来源：

SYNLETT | 2005年 / 01期

关键词：

condensation; ethers; lanthanides; Lewis acids; microwave;

D O I：

10.1055/s-2004-836063

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The lanthanide(III) trifluoromethanesulfonate-catalyzed condensation of benzyl alcohols with primary and secondary alcohols is described. This reaction proceeds readily with benzyl alcohols that have an alkyl or aryl substituent at the alpha-, ortho-, or para-position using microwave radiation or heating. The intramolecular variant of this reaction leads to cyclic benzofurans.

引用

页码：111 / 114

页数：4

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