ISEcp1-Mediated Transposition and Homologous Recombination Can Explain the Context of blaCTX-M-62 Linked to qnrB2

被引：39

作者：

Zong, Zhiyong ^{[1
,2
]}

Partridge, Sally R. ^{[1
]}

Iredell, Jonathan R. ^{[1
]}

机构：

[1] Univ Sydney, Westmead Hosp, Ctr Infect Dis & Microbiol, Sydney, NSW 2145, Australia

[2] Sichuan Univ, W China Hosp, Dept Infect Dis, Chengdu 610064, Peoples R China

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 07期

基金：

英国医学研究理事会;

关键词：

CLASS-1; INTEGRON; NATURAL PLASMIDS; GENE CASSETTES; EXPRESSION; IDENTIFICATION; MOBILIZATION; CTX-M-3; COPY; PCR;

D O I：

10.1128/AAC.00041-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

bla(CTX-M-62), a C508T variant of bla(CTX-M-3b), was transferred from Klebsiella pneumoniae JIE137 on a conjugative plasmid together with a class 1 integron containing the dfrA12-gcuF-aadA2 cassette array, ISCR1, and qnrB2. bla(CTX-M-62) lies between intact and rearranged copies of ISEcp1 in a configuration that can be explained by a combination of transposition and homologous recombination and which also illustrates the ability of ISEcp1 to mobilize an adjacent gene as part of transposition units of different sizes.

引用

页码：3039 / 3042

页数：4

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