AML with CBFB-MYH11 rearrangement demonstrate RAS pathway alterations in 92% of all cases including a high frequency of NF1 deletions

被引：51

作者：

Haferlach, C. ^{[1
]}

Dicker, F. ^{[1
]}

Kohlmann, A. ^{[1
]}

Schindela, S. ^{[1
]}

Weiss, T. ^{[1
]}

Kern, W. ^{[1
]}

Schnittger, S. ^{[1
]}

Haferlach, T. ^{[1
]}

机构：

[1] MLL Munich Leukemia Lab, Munich, Germany

来源：

LEUKEMIA | 2010年 / 24卷 / 05期

关键词：

ACUTE MYELOID-LEUKEMIA; GROUP-B; MUTATIONS; CANCER;

D O I：

10.1038/leu.2010.22

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：1065 / 1069

页数：6

共 8 条

[1] Exon 8 splice site mutations in the gene encoding the E3-ligase CBL are associated with core binding factor acute myeloid leukemias [J].

Abbas, Saman ;

Rotmans, Gabrielle ;

Lowenberg, Bob ;

Valk, Peter J. M. .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 (10) :1595-1597

[2] Implications of NRAS mutations in AML:: a study of 2502 patients [J].

Bacher, Ulrike ;

Haferlach, Torsten ;

Schoch, Claudia ;

Kern, Wolfgang ;

Schnittger, Susanne .

BLOOD, 2006, 107 (10) :3847-3853

[3] Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia [J].

Bullinger, Lars ;

Ruecker, Frank G. ;

Kurz, Stephan ;

Du, Juan ;

Scholl, Claudia ;

Sander, Sandrine ;

Corbacioglu, Andrea ;

Lottaz, Claudio ;

Froehling, Juergen ;

Ganser, Arnold ;

Schlenk, Richard F. ;

Doehner, Konstanze ;

Pollack, Jonathan R. ;

Doehner, Hartmut .

BLOOD, 2007, 110 (04) :1291-1300

[4] Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia [J].

Castilla, LH ;

Perrat, P ;

Martinez, NJ ;

Landrette, SF ;

Keys, R ;

Oikemus, S ;

Flanegan, J ;

Heilman, S ;

Garrett, L ;

Dutra, A ;

Anderson, S ;

Pihan, GA ;

Wolff, L ;

Liu, PP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (14) :4924-4929

[5] Nf1 deficiency cooperates with oncogenic K-RAS to induce acute myeloid leukemia in mice [J].

Cutts, Briony A. ;

Sjogren, Anna-Karin M. ;

Andersson, Karin M. E. ;

Wahlstrom, Annika M. ;

Karlsson, Christin ;

Swolin, Birgitta ;

Bergo, Martin O. .

BLOOD, 2009, 114 (17) :3629-3632

[6] Molecular genetics of human leukemias: New insights into therapy [J].

Gilliland, DG .

SEMINARS IN HEMATOLOGY, 2002, 39 (04) :6-11

[7] Patients with acute myeloid leukemia and RAS mutations benefit most from postremission high-dose cytarabine:: A Cancer and Leukemia Group B study [J].

Neubauer, Andreas ;

Maharry, Kati ;

Mrozek, Krzysztof ;

Thiede, Christian ;

Marcucci, Guido ;

Paschka, Peter ;

Mayer, Robert J. ;

Larson, Richard A. ;

Liu, Edison T. ;

Bloomfield, Clara D. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (28) :4603-4609

[8] Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21):: A Cancer and Leukemia Group B study [J].

Paschka, Peter ;

Marcucci, Guido ;

Ruppert, Amy S. ;

Mrozek, Krzysztof ;

Chen, Hankui ;

Kittles, Rick A. ;

Vukosavljevic, Tamara ;

Perrotti, Danilo ;

Vardiman, James W. ;

Carroll, Andrew J. ;

Kolitz, Jonathan E. ;

Larson, Richard A. ;

Bloomfield, Clara D. .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (24) :3904-3911

← 1 →