Aminomethylations via cross-coupling of potassium organotrifluoroborates with aryl bromides

被引：73

作者：

Molander, Gary A. ^{[1
]}

Sandrock, Deidre L. ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Roy & Diana A Vagelos Labs, Philadelphia, PA 19104 USA

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 08期

关键词：

D O I：

10.1021/ol070543e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The Suzuki-Miyaura cross-coupling reaction of N,N-dialkylaminomethyltrifluoroborates with aryl halides allows the construction of an aminomethyl aryl linkage through a disconnection based on dissonant reactivity patterns. A variety of these aminomethyltrifluoroborate substrates were prepared in good to excellent yields and then shown to cross-couple with equal facility to both electron-rich and electron-poor aryl halides as well as to a variety of heteroaromatic bromides.

引用

页码：1597 / 1600

页数：4

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