Chemical Composition, Antibacterial Screening and Cytotoxic Activity of Chiliadenus antiatlanticus (Asteraceae) Essential Oil

被引：8

作者：

El Yaagoubi, Mohamed ^{[1
]}

Ortiz, Sergio ^{[2
]}

Mechqoq, Hicham ^{[1
]}

Cavaleiro, Carlos ^{[3
,4
]}

Lecso-Bornet, Marylin ^{[2
]}

Rodrigues, Maria Joao ^{[5
]}

Custodio, Luisa ^{[5
]}

El Mousadik, Abdelhamid ^{[1
]}

Grougnet, Raphael ^{[2
]}

El Aouad, Noureddine ^{[1
,6
]}

Msanda, Fouad ^{[1
]}

Kritsanida, Marina ^{[2
]}

机构：

[1] Univ Ibn Zhor, Fac Sci, Lab Biotechnol & Valorizat Nat Resources, Agadir 80060, Morocco

[2] Univ Paris, Fac Pharm, CNRS, Nat Prod,Anal,Synth,UMR 8038,CiTCoM, F-75006 Paris, France

[3] Univ Coimbra, Fac Pharm, Hlth Sci Campus, P-3000548 Coimbra, Portugal

[4] Univ Coimbra, Chem Proc Engn & Forest Prod Res Ctr, Rua Silvio Lima,Polo II, P-3030790 Coimbra, Portugal

[5] Univ Algarve, Fac Sci & Technol, Ctr Marine Sci, Ed 7,Campus Gambelas, P-8005139 Faro, Portugal

[6] Univ Abdelmalek Essaadi, Polydisciplinary Fac Larache, Res Team Biol Engerineering Agrifood & Aquacultur, Larache 92000, Morocco

来源：

CHEMISTRY & BIODIVERSITY | 2021年 / 18卷 / 06期

基金：

欧盟地平线“2020”;

关键词：

Chiliadenus antiatlanticus; essential oil; camphor; intermedeol; antibacterial activity; IPHIONOIDES; LEAVES;

D O I：

10.1002/cbdv.202100115

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The chemical composition and in vitro antibacterial and cytotoxic activities of the essential oil (EO) of Chiliadenus antiatlanticus (Emb. & Maire) Gomiz, an asteraceous species endemic to the southwest of Morocco, were investigated. The EO yield was 1.07 +/- 0.28 %, twenty-seven metabolites were identified representing more than 96.4 % of the total composition. Camphor (35.7 %) and derivatives, borneol (4.9 %) and camphene (4.2 %) together with intermedeol (19.9 %), alpha-pinene (15.5 %) and (E)-pinocarveol (4.1 %) were the major constituents. An antibacterial activity was noticed against 24 strains (all Gram-positive) out of 71 at MICs values=100 mu g/mL. The EO also showed significant toxicity towards liver HepG2 (55.8 % of cell viability) and melanoma B16 4A5 (41.6 % of cell viability) tumor cell lines at 100 mu g/mL.

引用

页数：8

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