Progesterone treatment reduces disease severity and increases IL-10 in experimental autoimmune encephalomyelitis

被引：90

作者：

Yates, M. A. ^{[1
,2
]}

Li, Y. ^{[1
,2
]}

Chlebeck, P. ^{[1
]}

Proctor, T. ^{[1
]}

Vandenbark, A. A. ^{[1
,2
,3
]}

Offner, H. ^{[1
,2
,4
]}

机构：

[1] Portland VA Med Ctr, Portland, OR USA

[2] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97201 USA

[3] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, Portland, OR 97201 USA

[4] Oregon Hlth & Sci Univ, Dept Anesthesiol & Perioperat Med, Portland, OR 97201 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2010年 / 220卷 / 1-2期

关键词：

Progesterone; Estrogen; EAE; Multiple sclerosis; B cells; CENTRAL-NERVOUS-SYSTEM; CD8(+) T-CELLS; MULTIPLE-SCLEROSIS; DENDRITIC CELLS; ALPHA PRODUCTION; SPINAL-CORD; B-CELLS; ESTROGEN; MICE; EXPRESSION;

D O I：

10.1016/j.jneuroim.2010.01.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ovarian hormones, including progesterone, are known to have immunomodulatory and neuroprotective effects which may alter the disease course of experimental autoimmune encephalomyelitis (EAE). In the current study, we examined the treatment potential of progesterone beginning at the onset of EAE symptoms. Progesterone treated animals showed reduced peak disease scores and cumulative disease indices, and decreased inflammatory cytokine secretion (IL-2 and IL-17). In addition, increased production of IL-10 was accompanied by increased numbers of CD19+ cells and an increase in CD8+ cells. Decreased chemokine and chemokine receptor expression in the spinal cord also contributed to decreased lesions in the spinal cord. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：136 / 139

页数：4

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