Ionic Liquid-Based Suzuki Coupling Reaction: From Batch to Continuous Microflow System

被引：11

作者：

Bai, Lin ^{[1
]}

Fu, Yuhang ^{[1
]}

Cheng, Yi ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem Engn, Beijing 100084, Peoples R China

来源：

JOURNAL OF FLOW CHEMISTRY | 2017年 / 7卷 / 02期

关键词：

Suzuki-Miyaura reaction; ionic liquid; microreactor; flow chemistry; homogeneous; ORGANIC-SYNTHESIS; PALLADIUM; WATER; MICROREACTOR; COMPLEXES; CATALYSTS;

D O I：

10.1556/1846.2017.00002

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Transformed from heterogeneous to homogeneous state, an ionic liquid (IL)-based Suzuki coupling reaction was successfully implemented in a continuous microflow system. Triethylamine (Et3N) was introduced as the base, and N-methylpyrrolidinone (NMP) was used as the solvent of boronic acid, which brought about the first improvement on the reaction performance. Then, the implementation of this reaction in a continuous microflow system brought about further improvement on the reaction yield and selectivity due to better mixing condition. The combination of IL as the reaction medium and the continuous microflow system as the reactor in this work exhibited great potential for efficient Suzuki coupling reactions.

引用

页码：52 / 56

页数：5

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