C-Peptide replacement therapy in type 1 diabetes: are we in the trough of disillusionment?

被引：18

作者：

Pinger, C. W. ^{[1
,2
]}

Entwistle, K. E. ^{[1
]}

Bell, T. M. ^{[1
,2
]}

Liu, Y. ^{[1
]}

Spence, D. M. ^{[1
,2
]}

机构：

[1] Michigan State Univ, Dept Chem, 578 S Shaw Ln, E Lansing, MI 48824 USA

[2] Michigan State Univ, Dept Biomed Engn, Inst Quantitat Hlth Sci & Engn, 775 Woodlot Dr, E Lansing, MI 48824 USA

来源：

MOLECULAR BIOSYSTEMS | 2017年 / 13卷 / 08期

基金：

美国国家卫生研究院;

关键词：

HUMAN SERUM-ALBUMIN; FLUIDIC DEVICE; IN-VITRO; INSULIN; STREPTOZOTOCIN; GLYCATION; PATHOPHYSIOLOGY; POLYNEUROPATHY; COMPLICATIONS; ERYTHROCYTES;

D O I：

10.1039/c7mb00199a

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Type 1 diabetes is associated with such complications as blindness, kidney failure, and nerve damage. Replacing C-peptide, a hormone normally co-secreted with insulin, has been shown to reduce diabetes-related complications. Interestingly, after nearly 30 years of positive research results, C-peptide is still not being co-administered with insulin to diabetic patients. The following review discusses the potential of C-peptide as an auxilliary replacement therapy and why it's not currently being used as a therapeutic.

引用

页码：1432 / 1437

页数：6

共 50 条

[1] Review: Glycation of human serum albumin [J].

Anguizola, Jeanethe ;

Matsuda, Ryan ;

Barnaby, Omar S. ;

Hoy, K. S. ;

Wa, Chunling ;

DeBolt, Erin ;

Koke, Michelle ;

Hage, David S. .

CLINICA CHIMICA ACTA, 2013, 425 :64-76

[2]

[Anonymous], 2015, International Diabetes Federation Diabetes Atlas

[3]

Apfel S.C., 2007, Drug Discovery Today: Disease Models, V3, P397

[4] Further clinical experience with insulin (pancreatic extracts) in the treatment of diabetes mellitus [J].

Banting, FG ;

Campbell, WR ;

Fletcher, AA .

BRITISH MEDICAL JOURNAL, 1923, 1923 :8-12

[5] Impaired drug-binding capacities of in vitro and in vivo glycated albumin [J].

Baraka-Vidot, Jennifer ;

Guerin-Dubourg, Alexis ;

Bourdon, Emmanuel ;

Rondeau, Philippe .

BIOCHIMIE, 2012, 94 (09) :1960-1967

[6] Quantitative analysis of glycation patterns in human serum albumin using 16O/18O-labeling and MALDI-TOF MS [J].

Barnaby, Omar S. ;

Cerny, Ronald L. ;

Clarke, William ;

Hage, David S. .

CLINICA CHIMICA ACTA, 2011, 412 (17-18) :1606-1615

[7] Comparison of modification sites formed on human serum albumin at various stages of glycation [J].

Barnaby, Omar S. ;

Cerny, Ronald L. ;

Clarke, William ;

Hage, David S. .

CLINICA CHIMICA ACTA, 2011, 412 (3-4) :277-285

[8]

Cotter MA, 2001, DIABETES, V50, pA184

[9] Amelioration of sensory nerve dysfunction by C-peptide in patients with type 1 diabetes [J].

Ekberg, K ;

Brismar, T ;

Johansson, BL ;

Jonsson, B ;

Lindström, P ;

Wahren, J .

DIABETES, 2003, 52 (02) :536-541

[10]

Fenn J., 2008, Mastering the Hype Cycle: How to Choose the Right Innovation at the Right Time

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