Adenovirus endocytosis via αv integrins requires phosphoinositide-3-OH kinase

被引：196

作者：

Li, EG ^{[1
]}

Stupack, D ^{[1
]}

Klemke, R ^{[1
]}

Cheresh, DA ^{[1
]}

Nemerow, GR ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

来源：

JOURNAL OF VIROLOGY | 1998年 / 72卷 / 03期

关键词：

D O I：

10.1128/JVI.72.3.2055-2061.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Integrins mediate cell adhesion and motility on the extracellular matrix, yet they also promote viral attachment and/or entry. Evidence is presented that adenovirus internalization by alpha(v) integrins requires activation of phosphoinositide-3-OH kinase (PI3K), whereas alpha(v) integrin-mediated cell motility depends on the ERK1/ERK2 mitogen-activated protein kinase pathway. Interaction of adenovirus with alpha(v) integrins induced activation of PI3K. Pharmacologic or genetic disruption of endogenous PI3K activity blocked adenovirus internalization and virus-mediated gene delivery yet had no effect on integrin-mediated cell adhesion or motility, Therefore, integrin ligation engages distinct signaling pathways that promote viral endocytosis or cell movement.

引用

页码：2055 / 2061

页数：7

共 49 条

[1] A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages [J].