Simultaneous determination of proton pump inhibitors by high performance liquid chromatography with resonance Rayleigh scattering: A study of mechanism, performance and application

被引:4
|
作者
Zhang, Zhongying [1 ]
Ni, Ranxi [1 ]
Chen, Piao [1 ]
Zhu, Xiaolan [1 ]
Zhang, Zilong [1 ]
Peng, Jingdong [1 ]
机构
[1] Southwest Univ, Coll Chem & Chem Engn, 2 Tiansheng Rd, Chongqing, Peoples R China
关键词
HPLC; RRS; EY; PPIs; Pd(II); CAPILLARY-ELECTROPHORESIS; GOLD-NANOPARTICLE; LIGHT-SCATTERING; HUMAN URINE; HPLC METHOD; OMEPRAZOLE; FLUORESCENCE; LANSOPRAZOLE; PANTOPRAZOLE; METABOLITES;
D O I
10.1016/j.microc.2021.106259
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
In the present study, a convenient, selective and sensitive method of high performance liquid chromatography combined with resonance Rayleigh scattering (HPLC-RRS) for the detection of proton pump inhibitors (PPIs) was proposed based on enhancing the volume and hydrophobicity of PPIs by introducing Eosin Y (EY) and Pd(II). In order to investigate the interaction and the mechanism of signal enhancement, the complexes were characterized by ultraviolet-visible spectrum (UV), dynamic light scattering (DLS), RRS, scanning electron microscope (SEM) and the calculation of the density functional theory (DFT). The results indicated that PPIs, Pd(II) and EY formed ionic associations at 1:1:2 due to electrostatic attraction, which increased the volume and hydrophobicity of the system, resulting in the enhancement of RRS signals. Under the optimized experimental conditions, a linear relationship was found between RRS intensity and the concentration of PPIs within 0.02-25.00 mu g mL-1. The limits of detection were 10.1, 5.6, 7.5 and 8.3 ng mL-1 for rabeprazole, omeprazole, pantoprazole, and lansoprazole, respectively. In addition, the established simple, reliable and cheap method was validated and applied for the human serum samples, which indicated broad application prospects in drugs.
引用
收藏
页数:7
相关论文
共 50 条
  • [1] Simultaneous determination of cytokinins by high performance liquid chromatography with resonance Rayleigh scattering and mechanism discussion
    Zhang, Zhongying
    Peng, Jingdong
    Li, Shiyu
    Peng, Huanjun
    Wang, Xiang
    Long, Dengying
    Chen, Jun
    Xian, Hong
    Ni, Ranxi
    ANALYST, 2019, 144 (17) : 5186 - 5192
  • [2] High performance liquid chromatography associated with resonance Rayleigh scattering for synchronous determination of three antihistamines and mechanism study
    Li, Shiyu
    Peng, Jingdong
    Chen, Fang
    Pan, Ziyu
    Peng, Huanjun
    Chen, Yu
    He, Yan
    Wang, Xiang
    LUMINESCENCE, 2018, 33 (07) : 1171 - 1179
  • [3] Study on simultaneous determination of three nitroimidazole residues in honey by high performance liquid chromatography-resonance Rayleigh scattering spectra
    Chen, Fang
    Li, ShiYu
    Peng, Jingdong
    Wang, Xiang
    Peng, Huanjun
    Chen, Yu
    He, Yan
    MICROCHEMICAL JOURNAL, 2018, 141 : 423 - 430
  • [4] High performance liquid chromatography coupled with resonance Rayleigh scattering for the detection of three fluoroquinolones and mechanism study
    Zhou, Mingqiong
    Peng, Jingdong
    He, Rongxing
    He, Yuting
    Zhang, Jing
    Li, Aiping
    SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2015, 136 : 1181 - 1187
  • [5] Description and validation of coupling high performance liquid chromatography with resonance Rayleigh scattering in aminoglycosides determination
    Zhang, Lei
    Peng, Jingdong
    Tang, Jinxia
    Yuan, Binfang
    He, Rongxing
    Xiao, Ying
    ANALYTICA CHIMICA ACTA, 2011, 706 (02) : 199 - 204
  • [6] Determination of Indole Alkaloids by High-Performance Liquid Chromatography with Resonance Rayleigh Scattering Detection
    He, Yuting
    Peng, Jingdong
    Tang, Jinxia
    Zhou, Mingqiong
    Zhang, Cheng
    ANALYTICAL LETTERS, 2015, 48 (09) : 1380 - 1395
  • [7] Determination of netilmicin in rat serum using high performance liquid chromatography and resonance Rayleigh scattering
    Liu Chengwei
    Xu Qin
    Zhang Dan
    Lu Xin
    Zhao Shulin
    CHINESE JOURNAL OF CHROMATOGRAPHY, 2011, 29 (02) : 157 - 161
  • [8] Simultaneous determination of five fluoroquinolones by the selective high performance liquid chromatography associating with sensitive resonance light scattering and mechanism study
    Pan, Ziyu
    Peng, Jingdong
    Chen, Yi
    Zang, Xu
    Peng, Huanjun
    Bu, Lingli
    Xiao, Huan
    He, Yan
    Chen, Fang
    Chen, Yu
    MICROCHEMICAL JOURNAL, 2018, 136 : 71 - 79
  • [9] High performance liquid chromatography (HPLC) method coupled with resonance Rayleigh scattering detection for the determination of isepamicin
    Tang, Jinxia
    Peng, Jingdong
    Zhang, Lei
    Xiao, Ying
    ANALYTICAL METHODS, 2012, 4 (06) : 1833 - 1837
  • [10] Incorporation of high performance liquid chromatography with resonance Rayleigh scattering detection for determination of procaine and lidocaine in human plasma
    He, Yu Ting
    Peng, Jing Dong
    Tang, Jin Xia
    Zhang, Cheng
    ANALYTICAL METHODS, 2013, 5 (24) : 7110 - 7116