A novel PCR-RFLP assay for the detection of a polymorphism in the 3′ of STAT6 gene

被引：12

作者：

Amoli, M ^{[1
]}

Ollier, WER ^{[1
]}

Hajeer, A ^{[1
]}

机构：

[1] Univ Manchester, Manchester Med Sch, ARC Epidemiol Unit, Manchester M13 9PT, Lancs, England

来源：

GENES AND IMMUNITY | 2000年 / 1卷 / 05期

关键词：

STAT6; polymorphism; PCR-RFLP; biallelic;

D O I：

10.1038/sj.gene.6363684

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have identified a novel single nucleotide polymorphism at position 2964 (G/A) in the 3' untranslated region of the human STAT6 gene (GeneBank Accession No. U16031). A novel PCR-RFLP method has been devised for this polymorphism using the amplification-created restriction site (ACRS) method Allele frequencies in the UK Caucasian population were found to be 0.33 for allele A and 0.67 for allele G.

引用

页码：349 / 350

页数：2

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