Alternative splicing within the human cytochrome P450 superfamily with an emphasis on the brain: the convolution continues

被引:17
作者
Turman, Cheri M.
Hatley, Jade M.
Ryder, Daniel J.
Ravindranath, Vijayalakshmi
Strobel, Hen W.
机构
[1] Univ Texas, Sch Med, Dept Biochem & Mol Biol, Houston, TX 77030 USA
[2] Natl Brain Res Ctr, Manesar, Haryana, India
关键词
alternative splicing; brain CYPs; cytochrome P450; drug metabolism;
D O I
10.1517/17425255.2.3.399
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The human cytochrome P450 (CYP) superfamily of enzymes regulate hepatic phase 1 drug metabolism and subsequently play a significant role in pharmacokinetics, drug discovery and drug development. Alternative splicing of the cytochrome CYP gene transcripts enhances gene diversity and may play a role in transcriptional regulation of certain CYP proteins. Tissue-specific alternative splicing of CYPs is significant for its potential to add greater dimension to differential drug metabolism in hepatic and extrahepatic tissues, such as the brain, and to our understanding of the CYP family. This review provides an overview of tissue-specific splicing patterns, splicing types, regulation and the functional diversities between liver and splice variant CYP proteins and further explores the relevance of tissue-specific alternative splicing of CYPs in the nervous system.
引用
收藏
页码:399 / 418
页数:20
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