Ameliorative effect of resveratrol on testicular oxidative stress, spermatological parameters and DNA damage in glyphosate-based herbicide-exposed rats

被引：26
作者：
Avdatek, F. [1 ]
Birdane, Y. O. [2 ]
Turkmen, R. [2 ]
Demirel, H. H. [3 ]
机构：
[1] Afyon Kocatepe Univ, Fac Vet Med, Dept Reprod & Artificial Inseminat, Afyon, Turkey
[2] Afyon Kocatepe Univ, Fac Vet Med, Dept Pharmacol & Toxicol, Afyon, Turkey
[3] Afyon Kocatepe Univ, Bayat Vocat Sch, Dept Laborant & Vet Hlth, Afyon, Turkey
来源：
ANDROLOGIA | 2018年 / 50卷 / 07期
关键词：
antioxidant; glyphosate; rat; resveratrol; sperm; SPERM QUALITY; LIPID-PEROXIDATION; TESTOSTERONE LEVELS; TRANS-RESVERATROL; COMET ASSAY; ANTIOXIDANT; SUPPLEMENTATION; MORPHOLOGY; RAM; QUERCETIN;
D O I：
10.1111/and.13036
中图分类号：
R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
摘要：
In this study, the reproductive impacts of being exposed to glyphosate (GLF) and the protective impacts of resveratrol (RES) were assessed in 28 Wistar male rats, which were equally separated into four groups. Control group were fed normal diet without GLF or RES, group II received normal feed containing 20mg kg(-1) daily(-1) RES, group III received normal feed containing 375mg kg(-1) daily(-1) GLF, and group IV received normal feed containing 375mg kg(-1) daily(-1) GLF+20mg kg(-1) daily(-1) RES. GLF administration decreased sperm motility, sperm plasma membrane integrity, glutathione level and superoxide dismutase in the testicular tissue of rats. On the other hand, abnormal sperm rate, malondialdehyde level, and DNA damage were detected to be high in the group treated with GLF. The findings indicate that RES protects spermatological parameters and DNA damage, decreases GLF-induced lipid peroxidation, improves the antioxidant defence mechanism and regenerates tissue damage in the testis of rats.
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页数：8
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