Micro-RNA-15a and micro-RNA-16 expression and chromosome 13 deletions in multiple myeloma

被引：47
作者：
Corthals, Sophie L. [1 ]
Jongen-Lavrencic, Mojca [1 ]
de Knegt, Yvonne [1 ]
Peeters, Justine K. [1 ]
Beverloo, H. Berna [2 ]
Lokhorst, Henk M. [3 ]
Sonneveld, Pieter [1 ]
机构：
[1] Erasmus MC, Dept Hematol, NL-3000 CA Rotterdam, Netherlands
[2] Erasmus MC, Dept Clin Genet, NL-3000 CA Rotterdam, Netherlands
[3] Univ Med Ctr Utrecht, Dept Hematol, Utrecht, Netherlands
来源：
LEUKEMIA RESEARCH | 2010年 / 34卷 / 05期
关键词：
Multiple myeloma; Micro-RNA; Chromosome; 13; deletion; POOR-PROGNOSIS; ABNORMALITIES; CYTOGENETICS; MICRORNAS; SURVIVAL; THERAPY; CELLS; 13Q14; FISH; PCR;
D O I：
10.1016/j.leukres.2009.10.026
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We have used copy number variation (CNV) analysis with SNP mapping arrays for miRNA-15a and miRNA-16-1 expression analysis in patients with multiple myeloma (MM) with or without deletion of chromosome 13q14. MiRNA-15a and miRNA-16 display a range of expression patterns in MM patients, independent of the chromosome 13 status. These findings suggest that genes other than miR-15a and miR-16 may explain the prognostic significance of 13q14 deletions. (C) 2009 Elsevier Ltd. All rights reserved.
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收藏
页码：677 / 681
页数：5
相关论文
共 33 条
  • [1] Chromosome 13 abnormalities in multiple myeloma are mostly monosomy 13
    Avet-Loiseau, H
    Daviet, A
    Saunier, S
    Bataille, R
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2000, 111 (04) : 1116 - 1117
  • [2] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004)
    Bartel, David P.
    [J]. CELL, 2007, 131 (04) : 11 - 29
  • [3] Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    Calin, GA
    Dumitru, CD
    Shimizu, M
    Bichi, R
    Zupo, S
    Noch, E
    Aldler, H
    Rattan, S
    Keating, M
    Rai, K
    Rassenti, L
    Kipps, T
    Negrini, M
    Bullrich, F
    Croce, CM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (24) : 15524 - 15529
  • [4] Frequent monoallelic loss of D13S319 in multiple myeloma patients shown by interphase fluorescence in situ hybridization
    Chang, H
    Bouman, D
    Boerkoel, CF
    Stewart, AK
    Squire, JA
    [J]. LEUKEMIA, 1999, 13 (01) : 105 - 109
  • [5] Real-time quantification of microRNAs by stem-loop RT-PCR
    Chen, CF
    Ridzon, DA
    Broomer, AJ
    Zhou, ZH
    Lee, DH
    Nguyen, JT
    Barbisin, M
    Xu, NL
    Mahuvakar, VR
    Andersen, MR
    Lao, KQ
    Livak, KJ
    Guegler, KJ
    [J]. NUCLEIC ACIDS RESEARCH, 2005, 33 (20) : e179.1 - e179.9
  • [6] Deletion of chromosome 13 detected by conventional cytogenetics is a critical prognostic factor in myeloma
    Chiecchio, L.
    Protheroe, R. K. M.
    Ibrahim, A. H.
    Cheung, K. L.
    Rudduck, C.
    Dagrada, G. P.
    Cabanas, E. D.
    Parker, T.
    Nightingale, M.
    Wechalekar, A.
    Orchard, K. H.
    Harrison, C. J.
    Cross, N. C. P.
    Morgan, G. J.
    Ross, F. M.
    [J]. LEUKEMIA, 2006, 20 (09) : 1610 - 1617
  • [7] Prognostic factors for hyperdiploid-myeloma:: effects of chromosome 13 deletions and IgH translocations
    Chng, W
    Santana-Dávila, R
    Van Wier, S
    Ahmann, GJ
    Jalal, SM
    Bergsagel, PL
    Chesi, M
    Trendle, MC
    Jacobus, S
    Blood, E
    Oken, MM
    Henderson, K
    Kyle, RA
    Gertz, MA
    Lacy, MQ
    Dispenzieri, A
    Greipp, PR
    Fonseca, R
    [J]. LEUKEMIA, 2006, 20 (05) : 807 - 813
  • [8] Chromosome abnormalities clustering and its implications for pathogenesis and prognosis in myeloma
    Debes-Marun, CS
    Dewald, GW
    Bryant, S
    Picken, E
    Santana-Dávila, R
    González-Paz, N
    Winkler, JM
    Kyle, RA
    Gertz, MA
    Witzig, TE
    Dispenzieri, A
    Lacy, MQ
    Rajkumar, SV
    Lust, JA
    Greipp, PR
    Fonseca, R
    [J]. LEUKEMIA, 2003, 17 (02) : 427 - 436
  • [9] Relationship of patient survival and chromosome anomalies detected in metaphase and/or interphase cells at diagnosis of myeloma
    Dewald, GW
    Therneau, T
    Larson, D
    Lee, YK
    Fink, S
    Smoley, S
    Paternoster, S
    Adeyinka, A
    Ketterling, R
    Van Dyke, DL
    Fonseca, R
    Kyle, R
    [J]. BLOOD, 2005, 106 (10) : 3553 - 3558
  • [10] Genomic aberrations and survival in chronic lymphocytic leukemia.
    Döhner, H
    Stilgenbauer, S
    Benner, A
    Leupolt, E
    Kröber, A
    Bullinger, L
    Döhner, K
    Bentz, M
    Lichter, P
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (26) : 1910 - 1916
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