Mammalian single-strand break repair: Mechanisms and links with chromatin

被引：118
作者：
Caldecott, Keith W. [1 ]
机构：
[1] Univ Sussex, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England
来源：
DNA REPAIR | 2007年 / 6卷 / 04期
基金：
英国医学研究理事会;
关键词：
chromatin; base excision repair; XRCCI; PARP; DNA strand break repair;
D O I：
10.1016/j.dnarep.2006.10.006
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Thousands of cellular single-strand breaks (SSBs) arise in cells each day, from attack of deoxyribose and DNA bases by reactive oxygen species and other electrophilic molecules, and from the intrinsic instability of DNA. If not repaired, SSBs can disrupt transcription and replication and can be converted into potentially clastogenic and/or lethal DNA double-strand breaks. Here, I present an updated model for the repair of SSBs, and speculate on the possible impact of chromatin structure and remodelling on single-strand break repair (SSBR) processes. (c) 2006 Published by Elsevier B.V.
引用
收藏
页码：443 / 453
页数：11
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共 157 条
  • [11] DNA single-strand break repair and spinocerebellar ataxia
    Caldecott, KW
    [J]. CELL, 2003, 112 (01) : 7 - 10
  • [12] Mammalian DNA single-strand break repair: an X-ra(y)ted affair
    Caldecott, KW
    [J]. BIOESSAYS, 2001, 23 (05) : 447 - 455
  • [13] DNA single-strand breaks and neurodegeneration
    Caldecott, KW
    [J]. DNA REPAIR, 2004, 3 (8-9) : 875 - 882
  • [14] XRCC1 and DNA strand break repair
    Caldecott, KW
    [J]. DNA REPAIR, 2003, 2 (09) : 955 - 969
  • [15] AN INTERACTION BETWEEN THE MAMMALIAN DNA-REPAIR PROTEIN XRCC1 AND DNA LIGASE-III
    CALDECOTT, KW
    MCKEOWN, CK
    TUCKER, JD
    LJUNGQUIST, S
    THOMPSON, LH
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (01) : 68 - 76
  • [16] Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells
    Caldecott, KW
    Tucker, JD
    Stanker, LH
    Thompson, LH
    [J]. NUCLEIC ACIDS RESEARCH, 1995, 23 (23) : 4836 - 4843
  • [17] Involvement of XRCC1 and DNA ligase III gene products in DNA base excision repair
    Cappelli, E
    Taylor, R
    Cevasco, M
    Abbondandolo, A
    Caldecott, K
    Frosina, G
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (38) : 23970 - 23975
  • [18] 2 DISTINCT HUMAN DNA DIESTERASES THAT HYDROLYZE 3'-BLOCKING DEOXYRIBOSE FRAGMENTS FROM OXIDIZED DNA
    CHEN, DS
    HERMAN, T
    DEMPLE, B
    [J]. NUCLEIC ACIDS RESEARCH, 1991, 19 (21) : 5907 - 5914
  • [19] Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions
    D'Amours, D
    Desnoyers, S
    D'Silva, I
    Poirier, GG
    [J]. BIOCHEMICAL JOURNAL, 1999, 342 : 249 - 268
  • [20] Base excision repair is impaired in mammalian cells lacking poly(ADP-ribose) polymerase-1
    Dantzer, F
    de la Rubia, G
    Murcia, JMD
    Hostomsky, Z
    de Murcia, G
    Schreiber, V
    [J]. BIOCHEMISTRY, 2000, 39 (25) : 7559 - 7569
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