Generalized and tissue specific glucocorticoid resistance

被引：20
作者：
Martins, Clarissa Silva [1 ,2 ]
de Castro, Margaret [1 ]
机构：
[1] Univ Sao Paulo, Dept Internal Med, Ribeirao Preto Med Sch, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP, Brazil
[2] Univ Fed Mato Grosso do Sul, Sch Med, Campo Grande, MS, Brazil
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2021年 / 530卷
关键词：
Glucocorticoid signaling; Glucocorticoid receptor; Glucocorticoid resistance; LIGAND-BINDING DOMAIN; PITUITARY-ADRENAL AXIS; PRIMARY CORTISOL RESISTANCE; RECEPTOR GENE NR3C1; SITE-SPECIFIC PHOSPHORYLATION; ACUTE LYMPHOBLASTIC-LEUKEMIA; CARDIOVASCULAR-DISEASE RISK; STEROID-HORMONE RECEPTOR; CORONARY-ARTERY-DISEASE; HEAT-SHOCK PROTEINS;
D O I：
10.1016/j.mce.2021.111277
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Glucocorticoids (GCs) are steroid hormones that influence several physiologic functions and are among the most frequently prescribed drugs worldwide. Resistance to GCs has been observed in the context of the familial generalized GC resistance (Chrousos' syndrome) or tissue specific GC resistance in chronic inflammatory states. In this review, we have summarized the major factors that influence individual glucocorticoid sensitivity/ resistance. The fine-tuning of GC action is determined in a tissue-specific fashion that includes the combination of different GC receptor promoters, translation initiation sites, splice isoforms, interacting proteins, posttranslational modifications, and alternative mechanisms of signal transduction.
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页数：23
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