Preparation of magnetic and pH-responsive chitosan microcapsules via sonochemical method

被引：16
作者：
Xu, Fengzhi [1 ]
Zhao, Tianqi [1 ]
Wang, Shurong [2 ]
Liu, Songfeng [1 ]
Yang, Ting [1 ]
Li, Zhanfeng [1 ]
Wang, Hongyan [1 ]
Cui, Xuejun [1 ]
机构：
[1] Jilin Univ, Coll Chem, Changchun 130012, Peoples R China
[2] Jilin Univ, Hosp 2, Dept Ophthalmol, Changchun 130012, Peoples R China
来源：
JOURNAL OF MICROENCAPSULATION | 2016年 / 33卷 / 02期
关键词：
sonochemistry; microcapsules; pH-responsive; magnetic; chitosan; Drug delivery; ONE-STEP PREPARATION; SURFACE MODIFICATION; MICROSPHERES; IMMOBILIZATION; NANOPARTICLES; DERIVATIVES; CARRIERS; COMPLEX;
D O I：
10.3109/02652048.2016.1144817
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Magnetic and pH-responsive chitosan microcapsules (MPRCMCs) were prepared by a simple sonochemical method. Superparamagnetic oleic acid modified Fe3O4 nanoparticles (OA-Fe3O4 NPs) and hydrophobic drugs could be directly loaded into MPRCMCs during sonication. The obtained microcapsules had a well-defined spherical morphology with the average size of 2 mu m. The microcapsules showed an excellent magnetic property. In addition, the pH-responsive controlled release of coumarin 6 (C6) from MPRCMCs indicated that the developed microcapsules could be a promising candidate for drugs carriers.
引用
收藏
页码：191 / 198
页数：8
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