Ischemic Stroke Risk in Patients With Nonvalvular Atrial Fibrillation JACC Review Topic of the Week

被引：74

作者：

Alkhouli, Mohamad ^{[1
]}

Friedman, Paul A. ^{[1
]}

机构：

[1] Mayo Clin, Dept Cardiovasc Med, Rochester, MN USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2019年 / 74卷 / 24期

关键词：

atrial fibrillation; oral anticoagulation; risk assessment; stroke; C-REACTIVE PROTEIN; CHA(2)DS(2)-VASC SCORES PREDICT; ANTITHROMBOTIC THERAPY; FLOW VELOCITY; THROMBOEMBOLIC EVENTS; CARDIOVASCULAR EVENTS; ORAL ANTICOAGULATION; NATRIURETIC PEPTIDE; INTERATRIAL BLOCK; STRATIFICATION;

D O I：

10.1016/j.jacc.2019.10.040

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The last decade has witnessed remarkable advances in pharmacological and nonpharmacological strategies for stroke prevention in patients with atrial fibrillation. However, the currently available clinical stroke risk prediction models do not account for key nonclinical factors (arrhythmia burden, left atrial physiology and anatomy, chemical and electrocardiographic markers) and other competing clinical risks. Hence, their ability to identify patients who will derive the most benefit from pharmacological and mechanical risk prevention strategies remain limited. In this paper, the authors review the current and evolving ischemic stroke risk prediction schemes in patients with nonvalvular atrial fibrillation, highlight the strengths and weaknesses of the models, and discuss the unmet needs in this field. (C) 2019 by the American College of Cardiology Foundation.

引用

页码：3050 / 3065

页数：16

共 97 条

[1] Assessment and Impact of Cardiac Fibrosis on Atrial Fibrillation [J].

Akoum, Nazem ;

Marrouche, Nassir .

CURRENT CARDIOLOGY REPORTS, 2014, 16 (08)

[2] Stroke Prevention in Nonvalvular Atrial Fibrillation A Stakeholder Perspective [J].

Alkhouli, Mohamad ;

Noseworthy, Peter A. ;

Rihal, Charanjit S. ;

Holmes, David R., Jr. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2018, 71 (24) :2790-2801

[3] Burden of Atrial Fibrillation-Associated Ischemic Stroke in the United States [J].

Alkhouli, Mohamad ;

Alqahtani, Fahad ;

Aljohani, Sami ;

Alvi, Muhammad ;

Holmes, David R. .

JACC-CLINICAL ELECTROPHYSIOLOGY, 2018, 4 (05) :618-625

[4] PREDICTORS OF THROMBOEMBOLISM IN ATRIAL-FIBRILLATION .1. CLINICAL-FEATURES OF PATIENTS AT RISK [J].

ANDERSON, DC ;

ASINGER, RW ;

NEWBURG, SM ;

FARMER, CC ;

WANG, K ;

BUNDLIE, SR ;

KOLLER, RL ;

JAGIELLA, WM ;

KREHER, S ;

JORGENSEN, CR ;

SHARKEY, SW ;

FLAKER, GC ;

WEBEL, R ;

NOLTE, B ;

STEVENSON, P ;

BYER, J ;

WRIGHT, W ;

CHESEBRO, JH ;

WIEBERS, DO ;

HOLLAND, AE ;

MILLER, DM ;

BARDSLEY, WT ;

LITIN, SC ;

MEISSNER, I ;

ZERBE, DM ;

MCANULTY, JH ;

MARCHANT, C ;

COULL, BM ;

FELDMAN, G ;

HAYWARD, A ;

GANDARA, E ;

MACMILLAN, K ;

BLANK, N ;

LEONARD, AD ;

KANTER, MC ;

ISENSEE, LM ;

QUIROGA, ES ;

PRESTI, CH ;

TEGELER, CH ;

LOGAN, WR ;

HAMILTON, WP ;

GREEN, BJ ;

BACON, RS ;

REDD, RM ;

CADELL, DJ ;

GOMEZ, CR ;

JANOSIK, DL ;

LABOVITZ, AJ ;

KELLEY, RE ;

CHAHINE, R .

ANNALS OF INTERNAL MEDICINE, 1992, 116 (01) :1-5

[5]

ANDERSON DC, 1992, ANN INTERN MED, V116, P6

[6] 2018 Focused Update of the Canadian Cardiovascular Society Guidelines for the Management of Atrial Fibrillation [J].

Andrade, Jason G. ;

Verma, Atul ;

Mitchell, L. Brent ;

Parkash, Ratika ;

Leblanc, Kori ;

Atzema, Clare ;

Healey, Jeff S. ;

Bell, Alan ;

Cairns, John ;

Connolly, Stuart ;

Cox, Jafna ;

Dorian, Paul ;

Gladstone, David ;

McMurtry, M. Sean ;

Nair, Girish M. ;

Pilote, Louise ;

Sarrazin, Jean-Francois ;

Sharma, Mike ;

Skanes, Allan ;

Talajic, Mario ;

Tsang, Teresa ;

Verma, Subodh ;

Wyse, D. George ;

Nattel, Stanley ;

Macle, Laurent .

CANADIAN JOURNAL OF CARDIOLOGY, 2018, 34 (11) :1371-1392

[7]

[Anonymous], 1997, Arch Intern Med, V157, P1237

[8]

[Anonymous], J AM COLL CARDIOL IM

[9] Screening for cardiac contractile dysfunction using an artificial intelligence-enabled electrocardiogram [J].

Attia, Zachi I. ;

Kapa, Suraj ;

Lopez-Jimenez, Francisco ;

McKie, Paul M. ;

Ladewig, Dorothy J. ;

Satam, Gaurav ;

Pellikka, Patricia A. ;

Enriquez-Sarano, Maurice ;

Noseworthy, Peter A. ;

Munger, Thomas M. ;

Asirvatham, Samuel J. ;

Scott, Christopher G. ;

Carter, Rickey E. ;

Friedman, Paul A. .

NATURE MEDICINE, 2019, 25 (01) :70-+

[10] Interleukin-6 and C-reactive protein and risk for death and cardiovascular events in patients with atrial fibrillation [J].

Aulin, Julia ;

Siegbahn, Agneta ;

Hijazi, Ziad ;

Ezekowitz, Michael D. ;

Andersson, Ulrika ;

Connolly, Stuart J. ;

Huber, Kurt ;

Reilly, Paul A. ;

Wallentin, Lars ;

Oldgren, Jonas .

AMERICAN HEART JOURNAL, 2015, 170 (06) :1151-1160

← 1 2 3 4 5 6 7 8 9 10 →