Bioactive sesquiterpenes isolated from the essential oil of Dalbergia odorifera T. Chen

被引：34
|
作者：
Tao, Yi [1 ]
Wang, Yi [1 ]
机构：
[1] Zhejiang Univ, Inst Pharmaceut Informat, Hangzhou 310058, Zhejiang, Peoples R China
来源：
FITOTERAPIA | 2010年 / 81卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Dalbergia odorifera; Antithrombotic; Anti-platelet; Sesquiterpenes; CONSTITUENTS; ISOFLAVAN;
D O I：
10.1016/j.fitote.2009.11.012
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Investigation of the essential oil from the heartwood of Dalbergia odorifera T. Chen afforded the sesquiterpenes 1 and 2, that both showed anti-platelet activity. Their backbones were totally the same only with subtle difference in the chiral centre. Additionally, antithrombotic and antiplatelet activities of these two compounds were measured. The results showed that the antithrombotic activity of these two compounds was poor, while their anti-platelet activity was strong at middle and high concentrations. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：393 / 396
页数：4
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