The anthocyanin extracts from purple-fleshed sweet potato exhibited anti-photoaging effects on ultraviolent B-irradiated BALB/c-nu mouse skin

被引：32

作者：

Zhi, Qi ^{[1
]}

Lei, Lin ^{[1
]}

Li, Fuhua ^{[1
,2
]}

Zhao, Jichun ^{[1
,2
]}

Yin, Ran ^{[3
]}

Ming, Jian ^{[1
,2
]}

机构：

[1] Southwest Univ, Coll Food Sci, Tiansheng Rd 2, Chongqing 400715, Peoples R China

[2] Southwest Univ, Res Ctr Food Storage & Logist, Chongqing 400715, Peoples R China

[3] Rutgers State Univ, Ernest Mario Sch Pharm, 160 Frelinghuysen Rd, Piscataway, NJ 08854 USA

来源：

JOURNAL OF FUNCTIONAL FOODS | 2020年 / 64卷

基金：

中国国家自然科学基金;

关键词：

Purple-fleshed sweet potato; Anthocyanin; Anti-photoaging; MAPK; NF-kappa B; NF-KAPPA-B; INDUCED OXIDATIVE DAMAGE; SIGNALING PATHWAYS; INDUCED EXPRESSION; MAP KINASE; RADIATION; INHIBITION; INFLAMMATION; MECHANISMS; PROTEIN;

D O I：

10.1016/j.jff.2019.103640

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

This study investigated the effect of anthocyanin extracts from purple-fleshed sweet potato (PSP-AE) on ultraviolet B (UVB)-induced skin photoaging in BALB/c-nu mice. UPLC-QTOF-MS analysis showed six compounds were identified from PSP-AE. Administration of PSP-AE ameliorated the UVB-irradiated macroscopic and histopathological lesions of the skin via suppressing epidermal hyperplasia and collagen degradation, while improving the content of skin moisture and hydroxyproline. Additionally, PSP-AE inhibited the UVB-induced oxidative stress and increased the antioxidant enzyme activities. Results showed PSP-AE inhibited the UVB-irradiated levels of pro-inflammatory cytokines, such as tumor necrosis factor alpha and interleukin 6. Furthermore, Western blot analysis revealed PSP-AE remarkably decreased the protein levels of phosphorylated c-JunNterminal kinase, extracellular signal-regulated kinase, and p38. Likewise, UVB induced nuclear translocation of nuclear factor kappa-B and the expression of matrix metalloproteinase 1 were diminished by pretreatment of PSP-AE. Therefore, PSP-AE had the potential to attenuate the UVB-irradiated skin oxidative stress and inflammatory response.

引用

页数：9