Infection of novel reassortant H1N2 and H3N2 swine influenza A viruses in the guinea pig model

被引：15

作者：

Tapia, Rodrigo ^{[1
,2
]}

Garcia, Victoria ^{[1
]}

Mena, Juan ^{[1
]}

Bucarey, Sergio ^{[1
]}

Medina, Rafael A. ^{[3
,4
,5
]}

Neira, Victor ^{[1
]}

机构：

[1] Univ Chile, Fac Ciencias Vet & Pecuarias, Dept Med Prevent Anim, Santiago 11735, Chile

[2] Univ Chile, Programa Doctorado Ciencias Silvoagr & Vet, Santiago 11735, Chile

[3] Pontificia Univ Catolica Chile, Dept Enfermedades Infecciosas & Inmunol Pediat, Escuela Med, Santiago, Chile

[4] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA

[5] Millennium Inst Immunol & Immunotherapy, 391 Marcoleta, Santiago, Chile

来源：

VETERINARY RESEARCH | 2018年 / 49卷

关键词：

ANIMAL-MODELS; TRANSMISSION; PATHOGENESIS; VARIANT;

D O I：

10.1186/s13567-018-0572-4

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Novel H1N2 and H3N2 swine influenza A viruses (IAVs) were identified in commercial farms in Chile. These viruses contained H1, H3 and N2 sequences, genetically divergent from IAVs described worldwide, associated with pandemic internal genes. Guinea pigs were used as human surrogate to evaluate the infection dynamics of these reassortant viruses, compared with a pandemic H1N1 virus. All viruses replicated and were shed in the upper respiratory tract without prior adaptation although H1N2 viruses showed the highest shedding titers. This could have public health importance, emphasizing the need to carry out further studies to evaluate the zoonotic potential of these viruses.

引用

页数：8

共 50 条

[41] Interspecies Transmission of Reassortant Swine Influenza A Virus Containing Genes from Swine Influenza A(H1N1)pdm09 and A(H1N2) Viruses
Everett, Helen E.
Nash, Bethany
Londt, Brandon Z.
Kelly, Michael D.
Coward, Vivien
Nunez, Alejandro
van Diemen, Pauline M.
Brown, Ian H.
Brookes, Sharon M.
EMERGING INFECTIOUS DISEASES, 2020, 26 (02) : 273 - 281
[42] Complete Genome Sequences of Novel Reassortant H1N2 Swine Influenza Viruses Isolated from Pigs in the Republic of Korea
Pascua, Philippe Noriel Q.
Lim, Gyo-Jin
Kwon, Hyeok-il
Kim, Young-il
Kim, Eun-Ha
Park, Su-Jin
Kim, Se Mi
Decano, Arun G.
Choi, Eun-Ji
Jeon, Hae-Young
Kim, Chul-Joong
Choi, Young-Ki
GENOME ANNOUNCEMENTS, 2013, 1 (04)
[43] Emergence of H3N2 reassortant influenza A viruses in North American pigs
Zhou, NN
Senne, DA
Landgraf, JS
Swenson, SL
Erickson, G
Rossow, K
Liu, L
Yoon, KJ
Krauss, S
Webster, RG
VETERINARY MICROBIOLOGY, 2000, 74 (1-2) : 47 - 58
[44] Interspecies and intraspecies transmission of triple reassortant H3N2 influenza A viruses
Yassine, Hadi M.
Al-Natour, Mohammad Q.
Lee, Chang-Won
Saif, Yehya M.
VIROLOGY JOURNAL, 2007, 4 (1)
[45] Interspecies and intraspecies transmission of triple reassortant H3N2 influenza A viruses
Hadi M Yassine
Mohammad Q Al-Natour
Chang-Won Lee
Yehia M Saif
Virology Journal, 4
[46] Emergence of influenza A H1N2 reassortant viruses in the human population during 2001
Gregory, V
Bennett, M
Orkhan, MH
Al Hajjar, S
Varsano, N
Mendelson, E
Zambon, M
Ellis, J
Hay, A
Lin, YP
VIROLOGY, 2002, 300 (01) : 1 - 7
[47] Viral reassortment and transmission after co-infection of pigs with classical H1N1 and triple-reassortant H3N2 swine influenza viruses
Ma, Wenjun
Lager, Kelly M.
Lekcharoensuk, Porntippa
Ulery, Eva S.
Janke, Bruce H.
Solorzano, Alicia
Webby, Richard J.
Garcia-Sastre, Adolfo
Richt, Juergen A.
JOURNAL OF GENERAL VIROLOGY, 2010, 91 : 2314 - 2321
[48] ISOLATION OF 2 H1N2 INFLUENZA-VIRUSES FROM SWINE IN FRANCE
GOURREAU, JM
KAISER, C
VALETTE, M
DOUGLAS, AR
LABIE, J
AYMARD, M
ARCHIVES OF VIROLOGY, 1994, 135 (3-4) : 365 - 382
[49] Protection against a European H1N2 swine influenza virus in pigs previously infected with H1N1 and/or H3N2 subtypes
Van Reeth, K
Gregory, V
Hay, A
Pensaert, M
VACCINE, 2003, 21 (13-14) : 1375 - 1381
[50] Evolution of swine H3N2 influenza viruses in the United States
Webby, RJ
Swenson, SL
Krauss, SL
Gerrish, PJ
Goyal, SM
Webster, RG
JOURNAL OF VIROLOGY, 2000, 74 (18) : 8243 - 8251

← 1 2 3 4 5 →