Infection of novel reassortant H1N2 and H3N2 swine influenza A viruses in the guinea pig model

被引：15

作者：

Tapia, Rodrigo ^{[1
,2
]}

Garcia, Victoria ^{[1
]}

Mena, Juan ^{[1
]}

Bucarey, Sergio ^{[1
]}

Medina, Rafael A. ^{[3
,4
,5
]}

Neira, Victor ^{[1
]}

机构：

[1] Univ Chile, Fac Ciencias Vet & Pecuarias, Dept Med Prevent Anim, Santiago 11735, Chile

[2] Univ Chile, Programa Doctorado Ciencias Silvoagr & Vet, Santiago 11735, Chile

[3] Pontificia Univ Catolica Chile, Dept Enfermedades Infecciosas & Inmunol Pediat, Escuela Med, Santiago, Chile

[4] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA

[5] Millennium Inst Immunol & Immunotherapy, 391 Marcoleta, Santiago, Chile

来源：

VETERINARY RESEARCH | 2018年 / 49卷

关键词：

ANIMAL-MODELS; TRANSMISSION; PATHOGENESIS; VARIANT;

D O I：

10.1186/s13567-018-0572-4

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Novel H1N2 and H3N2 swine influenza A viruses (IAVs) were identified in commercial farms in Chile. These viruses contained H1, H3 and N2 sequences, genetically divergent from IAVs described worldwide, associated with pandemic internal genes. Guinea pigs were used as human surrogate to evaluate the infection dynamics of these reassortant viruses, compared with a pandemic H1N1 virus. All viruses replicated and were shed in the upper respiratory tract without prior adaptation although H1N2 viruses showed the highest shedding titers. This could have public health importance, emphasizing the need to carry out further studies to evaluate the zoonotic potential of these viruses.

引用

页数：8

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