Useful agents against aflatoxin B1 - antibacterial azomethine and Mn(III) complexes involving L-Threonine, L-Serine, and L-Tyrosine

被引：11
作者：
Anar, Mustafa [1 ]
Ozkan, Elvan Hasanoglu [2 ]
Ogutcu, Hatice [3 ]
Agar, Guleray [1 ]
Sakiyan, Iffet [4 ]
Sari, Nursen [2 ]
机构：
[1] Ataturk Univ, Dept Mol Biol & Genet, Erzurum, Turkey
[2] Gazi Univ, Dept Chem, Ankara, Turkey
[3] Ahi Evran Univ, Dept Biol, Kirsehir, Turkey
[4] Ankara Univ, Dept Chem, TR-06100 Ankara, Turkey
来源：
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2016年 / 44卷 / 03期
关键词：
antimicrobial properties; aflatoxin B; Mn(III) complexes; mutagenicity; AMINO-ACIDS; EPOXIDATION; GLUTAMINE;
D O I：
10.3109/21691401.2014.991792
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The present study is focused on evaluating the antimutagenic properties of Schiff bases and Mn(III) complexes with L-Threonine, L-Serine and L-Tyrosine, which have antimicrobial activity. These six compounds were investigated for antimutagenic properties against Aflatoxin B (AFB) by the micronucleus (MN) assay in a human lymphocyte cell culture in vitro. The protective role of these compounds against AFB-induced MN is probably related to its doses. A mechanism has been proposed to reduce the effect of AFB.
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收藏
页码：853 / 858
页数：6
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