Injectable bone cement based on mineralized collagen

被引：33

作者：

Liu, Xi ^{[1
]}

Wang, Xiu-Mei ^{[1
]}

Chen, Zonggang ^{[1
]}

Cui, Fu-Zhai ^{[1
]}

Liu, Huan-Ye ^{[1
]}

Mao, Keya ^{[2
]}

Wang, Yan ^{[2
]}

机构：

[1] Tsinghua Univ, State Key Lab New Ceram & Fine Proc, Dept Mat Sci & Engn, Beijing 100084, Peoples R China

[2] Gen Hosp Peoples Liberat Army, Dept Orthoped, Beijing 100853, Peoples R China

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS | 2010年 / 94B卷 / 01期

基金：

中国国家自然科学基金;

关键词：

bone cement; injectable; mineralized collagen; calcium sulfate hemihydrate; biocompatibility; IN-VITRO BIOACTIVITY; CALCIUM; PLASTER; BEHAVIOR; SCAFFOLD; CELLS; PARIS;

D O I：

10.1002/jbm.b.31625

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A novel injectable bone cement based on mineralized collagen was reported in this paper. The cement was fabricated by introducing calcium sulfate hemihydrate (CaSO4 center dot 1/2H(2)O, CSH) into nano-hydroxyapatite/collagen (nHAC). The workability, in vitro degradation, in vitro and in vivo biocompatibility of the cement (nHAC/CSH) were studied. The comparative tests via in vitro and in vivo showed that the nHAC/CSH composite cement processed better biocompatibiltiy than that of pure CSH cement. The results implied that this new injectable cement should be very promising for bone repair. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 94B: 72-79, 2010.

引用

页码：72 / 79

页数：8

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