Safe provision of systemic anti-cancer treatment for urological cancer patients during COVID-19: a tertiary centre experience in the first wave of COVID-19

被引：0

作者：

So, Alfred Chung Pui ^{[1
]}

Karampera, Christina ^{[1
]}

Khan, Muhammad ^{[1
]}

Russell, Beth ^{[2
]}

Moss, Charlotte ^{[2
]}

Monroy-Iglesias, Maria J. ^{[2
]}

Thillai, Kiruthikah ^{[1
]}

Josephs, Debra Hannah ^{[1
]}

Pintus, Elias ^{[1
]}

Rudman, Sarah ^{[1
]}

Van Hemelrijck, Mieke ^{[2
]}

Dolly, Saoirse ^{[1
]}

Enting, Deborah ^{[1
]}

机构：

[1] Guys & St Thomas NHS Fdn Trust, Dept Oncol, London SE1 9RT, England

[2] Kings Coll London, Sch Canc & Pharmaceut Sci, Translat Oncol & Urol Res TOUR, London SE1 9RT, England

来源：

BMC UROLOGY | 2022年 / 22卷 / 01期

关键词：

SEVERITY; DISEASE; IMPACT;

D O I：

10.1186/s12894-022-01023-6

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Safe provision of systemic anti-cancer treatment (SACT) during the COVID-19 pandemic remains an ongoing concern amongst clinicians. Methods: Retrospective analysis on uro-oncology patients who continued or started SACT between 1st March and 31st May 2020 during the pandemic (with 2019 as a comparator). Results: 441 patients received SACT in 2020 (292 prostate, 101 renal, 38 urothelial, 10 testicular) compared to 518 patients in 2019 (340 prostate, 121 renal, 42 urothelial, 15 testicular). In 2020, there were 75.00% fewer patients with stage 3 cancers receiving SACT (p < 0.0001) and 94.44% fewer patients receiving radical treatment (p = 0.00194). The number of patients started on a new line of SACT was similar between both years (118 in 2019 vs 102 in 2020; p= 0.898) but with 53.45% fewer patients started on chemotherapy in 2020 (p < 0.001). Overall, 5 patients tested positive for COVID-19 (one asymptomatic, one mild, two moderate, one severe resulting in death). Compared to 2019, 30-day mortality was similar (1.69% in 2019 vs 0.98% in 2020; p= 0.649) whereas 6-month mortality was lower (9.32% in 2019 vs 1.96% in 2020; p = 0.0209) in 2020. Conclusion: This study suggests that delivery of SACT to uro-oncology patients during COVID-19 pandemic may be safe in high-incidence areas with appropriate risk-reduction strategies.

引用

页数：10

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