Caenorhabditis elegans: A New Model Organism for Studies of Axon Regeneration

被引：31
作者：
Ghosh-Roy, Anindya [1 ]
Chisholm, Andrew D. [1 ]
机构：
[1] Univ Calif San Diego, Div Biol Sci, Neurobiol Sect, La Jolla, CA 92093 USA
来源：
DEVELOPMENTAL DYNAMICS | 2010年 / 239卷 / 05期
关键词：
laser axotomy; DLK kinase; axon guidance; myelin; Wallerian degeneration; mechanosensory neuron; FEMTOSECOND LASER-ABLATION; MAP KINASE PATHWAY; C; ELEGANS; NERVE REGENERATION; CNS; INHIBITOR; AXOTOMY; GROWTH; DLK-1; STAGE;
D O I：
10.1002/dvdy.22253
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Axonal regeneration in Caenorhabditis elegans was first reported five years ago. Individual green fluorescent protein-labeled axons can be severed using laser microsurgery and their regrowth followed in vivo. Several neuron types display robust regrowth after injury, including motor and sensory neurons. The small size and transparency of C. elegans make possible large-scale genetic and pharmacological screens for regeneration phenotypes. Developmental Dynamics 239:1460-1464, 2010. (C) 2010 Wiley-Liss, Inc.
引用
收藏
页码：1460 / 1464
页数：5
相关论文
共 50 条
  • [41] High uric acid model in Caenorhabditis elegans
    Li, Zhenjing
    Xue, Yibin
    Wang, Nifei
    Cheng, Jingli
    Dong, Xiaoying
    Guo, Qingbin
    Wang, Changlu
    FOOD SCIENCE AND HUMAN WELLNESS, 2019, 8 (01) : 63 - 66
  • [42] A Caenorhabditis elegans Model System for Amylopathy Study
    Duan, Zhibing
    Sesti, Federico
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2013, (75):
  • [43] A New Player in the Spermiogenesis Pathway of Caenorhabditis elegans
    LaMunyon, Craig W.
    Nasri, Ubaydah
    Sullivan, Nicholas G.
    Shaw, Misa A.
    Prajapati, Gaurav
    Christensen, Matthew
    Elmatari, Daniel
    Clark, Jessica N.
    GENETICS, 2015, 201 (03) : 1103 - 1116
  • [44] Japanese studies on neural circuits and behavior of Caenorhabditis elegans
    Sasakura, Hiroyuki
    Tsukada, Yuki
    Takagi, Shin
    Mori, Ikue
    FRONTIERS IN NEURAL CIRCUITS, 2013, 7 : 187
  • [45] Regulators of H3K4 methylation mutated in neurodevelopmental disorders control axon guidance in Caenorhabditis elegans
    Abay-Norgaard, Steffen
    Attianese, Benedetta
    Boreggio, Laura
    Salcini, Anna Elisabetta
    DEVELOPMENT, 2020, 147 (15):
  • [46] Growth cones stall and collapse during axon outgrowth in Caenorhabditis elegans
    Knobel, KM
    Jorgensen, EM
    Bastiani, MJ
    DEVELOPMENT, 1999, 126 (20): : 4489 - 4498
  • [47] Constructing a Low-budget Laser Axotomy System to Study Axon Regeneration in C-elegans
    Williams, Wes
    Nix, Paola
    Bastiani, Michael
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2011, (57):
  • [48] Toxicity of silver nanoparticles, multiwalled carbon nanotubes, and dendrimers assessed with multicellular organism Caenorhabditis elegans
    Walczynska, Marta
    Jakubowski, Witold
    Wasiak, Tomasz
    Kadziola, Kinga
    Bartoszek, Nina
    Kotarba, Sylwia
    Siatkowska, Malgorzata
    Komorowski, Piotr
    Walkowiak, Bogdan
    TOXICOLOGY MECHANISMS AND METHODS, 2018, 28 (06) : 432 - 439
  • [49] A neuronal MAP kinase constrains growth of a Caenorhabditis elegans sensory dendrite throughout the life of the organism
    McLachlan, Ian G.
    Beets, Isabel
    de Bono, Mario
    Heiman, Maxwell G.
    PLOS GENETICS, 2018, 14 (06):
  • [50] Copper Homeostasis in the Model Organism C. elegans
    Ohse, Verena Alexia
    Klotz, Lars-Oliver
    Priebs, Josephine
    CELLS, 2024, 13 (09)
12345