Caenorhabditis elegans: A New Model Organism for Studies of Axon Regeneration

被引：31

作者：

Ghosh-Roy, Anindya ^{[1
]}

Chisholm, Andrew D. ^{[1
]}

机构：

[1] Univ Calif San Diego, Div Biol Sci, Neurobiol Sect, La Jolla, CA 92093 USA

来源：

DEVELOPMENTAL DYNAMICS | 2010年 / 239卷 / 05期

关键词：

laser axotomy; DLK kinase; axon guidance; myelin; Wallerian degeneration; mechanosensory neuron; FEMTOSECOND LASER-ABLATION; MAP KINASE PATHWAY; C; ELEGANS; NERVE REGENERATION; CNS; INHIBITOR; AXOTOMY; GROWTH; DLK-1; STAGE;

D O I：

10.1002/dvdy.22253

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Axonal regeneration in Caenorhabditis elegans was first reported five years ago. Individual green fluorescent protein-labeled axons can be severed using laser microsurgery and their regrowth followed in vivo. Several neuron types display robust regrowth after injury, including motor and sensory neurons. The small size and transparency of C. elegans make possible large-scale genetic and pharmacological screens for regeneration phenotypes. Developmental Dynamics 239:1460-1464, 2010. (C) 2010 Wiley-Liss, Inc.

引用

页码：1460 / 1464

页数：5

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